| Literature DB >> 25531942 |
Carsten Linnemann1, Marit M van Buuren1, Laura Bies1, Els M E Verdegaal2, Remko Schotte3, Jorg J A Calis1, Sam Behjati4, Arno Velds5, Henk Hilkmann6, Dris El Atmioui6, Marten Visser2, Michael R Stratton4, John B A G Haanen7, Hergen Spits3, Sjoerd H van der Burg2, Ton N M Schumacher1.
Abstract
Tumor-specific neo-antigens that arise as a consequence of mutations are thought to be important for the therapeutic efficacy of cancer immunotherapies. Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo-antigen-specific CD4+ T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4+ T-cell responses in tumor control, we addressed whether neo-antigen-specific CD4+ T-cell reactivity is a common property in human melanoma.Entities:
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Year: 2014 PMID： 25531942 DOI： 10.1038/nm.3773
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440