Literature DB >> 2553188

Selectivity of bradykinin analogues for receptors mediating contraction and relaxation of the rat duodenum.

A C Paiva1, T B Paiva, C C Pereira, S I Shimuta.   

Abstract

1. Bradykinin produces a biphasic response in the rat duodenum that consists of a relaxation (pD2 = 8.44) followed by a contraction (pD2 = 6.91). 2. The B1 agonist des-Arg9-bradykinin produced a contraction (pD2 = 7.16) but no relaxation. Des-Arg9-[Leu8]-bradykinin, which is a B1 antagonist in other systems produced contraction (pD2 = 7.65) in the rat duodenum. 3. Four bradykinin analogues that are preferential B2 agonists in other tissues had a biphasic effect with pD2 values in the range 7.22-8.68 for relaxation and 6.26-6.91 for contraction. 4. [Thi5,8,D-Phe7]-bradykinin, which is a B2 antagonist in most other systems produced relaxation in the rat duodenum, with a pD2 of 7.49. 5. It is concluded that the contractile component of the response to bradykinin in rat duodenum may be mediated by a subtype of the B1 receptor and the relaxant component by a receptor of the B2 subtype.

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Year:  1989        PMID： 2553188      PMCID： PMC1854693          DOI： 10.1111/j.1476-5381.1989.tb16883.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  12 in total

1.  A study of some bradykinin potentiating peptides derived from plasma proteins.

Authors:  D B Faber; C Van der Meer
Journal:  Arch Int Pharmacodyn Ther       Date:  1973-10

2.  The relaxing effect of bradykinin on intestinal smooth muscle.

Authors:  A Antonio
Journal:  Br J Pharmacol Chemother       Date:  1968-01

Review 3.  Pharmacology of bradykinin and related kinins.

Authors:  D Regoli; J Barabé
Journal:  Pharmacol Rev       Date:  1980-03       Impact factor: 25.468

4.  The effect of catecholamine depletion on the bradykinin-induced relaxation of isolated smooth muscle.

Authors:  J G Ufkes; C Van der Meer
Journal:  Eur J Pharmacol       Date:  1975-08       Impact factor: 4.432

5.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03

6.  Identification of pre- and postsynaptic bradykinin receptor sites in the vas deferens: evidence for different structural prerequisites.

Authors:  I Llona; R Vavrek; J Stewart; J P Huidobro-Toro
Journal:  J Pharmacol Exp Ther       Date:  1987-05       Impact factor: 4.030

7.  Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines.

Authors:  A Camargo; S H Ferreira
Journal:  Br J Pharmacol       Date:  1971-06       Impact factor: 8.739

8.  Bradykinin action in the rat duodenum: receptor binding and influence on the cyclic AMP system.

Authors:  C Liebmann; S Reissmann; P Robberecht; H Arold
Journal:  Biomed Biochim Acta       Date:  1987

9.  Competitive antagonists of bradykinin.

Authors:  R J Vavrek; J M Stewart
Journal:  Peptides       Date:  1985 Mar-Apr       Impact factor: 3.750

10.  The actions of kinin antagonists on B1 and B2 receptor systems.

Authors:  D Regoli; G Drapeau; P Rovero; S Dion; P D'Orléans-Juste; J Barabé
Journal:  Eur J Pharmacol       Date:  1986-04-09       Impact factor: 4.432
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  8 in total

1.  Bradykinin stimulates production of inositol (1,4,5) trisphosphate in cultured mesangial cells of the rat via a BK2-kinin receptor.

Authors:  J L Bascands; C Emond; C Pecher; D Regoli; J P Girolami
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

2.  Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats.

Authors:  P Belichard; J M Luccarini; E Defrêne; P Faye; R M Franck; H Duclos; J L Paquet; D Pruneau
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

3.  Pharmacologic characteristics of rabbit esophageal muscularis mucosae in vitro.

Authors:  W H Percy; A J Miller; J T Brunz
Journal:  Dig Dis Sci       Date:  1997-12       Impact factor: 3.199

4.  BK1 and BK2 bradykinin receptors in the rat duodenum smooth muscle.

Authors:  T Feres; A C Paiva; T B Paiva
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

5.  Kinin-induced relaxations of the rat duodenum.

Authors:  T Griesbacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

6.  Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium.

Authors:  T Feres; L M Vianna; A C Paiva; T B Paiva
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

7.  The longitudinal muscle of rat ileum as a sensitive monoreceptor assay for bradykinin B1 receptors.

Authors:  S Meini; A Lecci; C A Maggi
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

8.  Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice.

Authors:  Dorinne Desposito; Georges Zadigue; Christopher Taveau; Clovis Adam; François Alhenc-Gelas; Nadine Bouby; Ronan Roussel
Journal:  Sci Rep       Date:  2017-08-25       Impact factor: 4.379
  8 in total

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