BACKGROUND/AIMS: In term subjects, fat mass (FM) is positively associated with leptin, whereas studies in preterm infants show conflicting results. However, none of these studies measured FM by dual-energy X-ray absorptiometry (DEXA). This study aims to relate FM measured by DEXA in relation to leptin and growth in preterm infants. METHODS: In 139 preterm infants, weight (kg) and length (cm) were measured at birth, term age, and 6 months' corrected age (CA). FM (kg), measured by whole-body DEXA, and leptin (µg/l) were measured at term age and 6 months' CA. RESULTS: At term age and 6 months' CA, FM was associated with leptin (β = 1.94, 95% CI: 1.51-2.36, and β = 0.37, 95% CI: 0.26-0.48, respectively; p < 0.001). Gain in weight standard deviation score (SDS) between term age and 6 months' CA was associated with FM and leptin at 6 months' CA (β = 0.24, 95% CI: 0.18-0.30, and β = 0.25, 95% CI: 0.16-0.33, respectively; p < 0.001). CONCLUSION: In preterm infants, FM measured by DEXA is associated with leptin, which indicates that leptin is a marker of body FM during the first 6 months after term age. Gain in weight SDS between term age and 6 months' CA results in higher FM and higher leptin at 6 months' CA.
BACKGROUND/AIMS: In term subjects, fat mass (FM) is positively associated with leptin, whereas studies in preterm infants show conflicting results. However, none of these studies measured FM by dual-energy X-ray absorptiometry (DEXA). This study aims to relate FM measured by DEXA in relation to leptin and growth in preterm infants. METHODS: In 139 preterm infants, weight (kg) and length (cm) were measured at birth, term age, and 6 months' corrected age (CA). FM (kg), measured by whole-body DEXA, and leptin (µg/l) were measured at term age and 6 months' CA. RESULTS: At term age and 6 months' CA, FM was associated with leptin (β = 1.94, 95% CI: 1.51-2.36, and β = 0.37, 95% CI: 0.26-0.48, respectively; p < 0.001). Gain in weight standard deviation score (SDS) between term age and 6 months' CA was associated with FM and leptin at 6 months' CA (β = 0.24, 95% CI: 0.18-0.30, and β = 0.25, 95% CI: 0.16-0.33, respectively; p < 0.001). CONCLUSION: In preterm infants, FM measured by DEXA is associated with leptin, which indicates that leptin is a marker of body FM during the first 6 months after term age. Gain in weight SDS between term age and 6 months' CA results in higher FM and higher leptin at 6 months' CA.
Authors: Lea Sophie Möllers; Efrah I Yousuf; Constanze Hamatschek; Katherine M Morrison; Michael Hermanussen; Christoph Fusch; Niels Rochow Journal: Pediatr Res Date: 2021-05-26 Impact factor: 3.953
Authors: Elin W Blakstad; Sissel J Moltu; Britt Nakstad; Marit B Veierød; Kenneth Strømmen; Pétur B Júlíusson; Astrid N Almaas; Arild E Rønnestad; Kristin Brække; Christian A Drevon; Per O Iversen Journal: Food Nutr Res Date: 2016-12-01 Impact factor: 3.894
Authors: María Dolores Ordóñez-Díaz; Mercedes Gil-Campos; Katherine Flores-Rojas; María Carmen Muñoz-Villanueva; Concepción María Aguilera-García; María Jose de la Torre-Aguilar; Juan Luis Pérez-Navero Journal: Nutrients Date: 2020-04-24 Impact factor: 5.717