Literature DB >> 25530853

Shape Transformation Following Reduction-Sensitive PEG Cleavage of Polymer/DNA Nanoparticles.

John-Michael Williford1, Yong Ren2, Kevin Huang3, Deng Pan4, Hai-Quan Mao2.   

Abstract

PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surface charges, correlating with improved transfection efficiency.

Entities:  

Year:  2014        PMID： 25530853      PMCID： PMC4269835          DOI： 10.1039/C4TB00967C

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


  29 in total

1.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

Authors:  B Devika Chithrani; Arezou A Ghazani; Warren C W Chan
Journal:  Nano Lett       Date:  2006-04       Impact factor: 11.189

2.  Shape effects of filaments versus spherical particles in flow and drug delivery.

Authors:  Yan Geng; Paul Dalhaimer; Shenshen Cai; Richard Tsai; Manorama Tewari; Tamara Minko; Dennis E Discher
Journal:  Nat Nanotechnol       Date:  2007-03-25       Impact factor: 39.213

3.  The effect of particle design on cellular internalization pathways.

Authors:  Stephanie E A Gratton; Patricia A Ropp; Patrick D Pohlhaus; J Christopher Luft; Victoria J Madden; Mary E Napier; Joseph M DeSimone
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-12       Impact factor: 11.205

4.  Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium.

Authors:  Poornima Kolhar; Aaron C Anselmo; Vivek Gupta; Kapil Pant; Balabhaskar Prabhakarpandian; Erkki Ruoslahti; Samir Mitragotri
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-10       Impact factor: 11.205

5.  Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.

Authors:  Xuan Jiang; Wei Qu; Deng Pan; Yong Ren; John-Michael Williford; Honggang Cui; Erik Luijten; Hai-Quan Mao
Journal:  Adv Mater       Date:  2012-10-11       Impact factor: 30.849

6.  Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery.

Authors:  Xian-Zhu Yang; Jin-Zhi Du; Shuang Dou; Cheng-Qiong Mao; Hong-Yan Long; Jun Wang
Journal:  ACS Nano       Date:  2011-12-09       Impact factor: 15.881

7.  Polyion complex micelles as vectors in gene therapy--pharmacokinetics and in vivo gene transfer.

Authors:  M Harada-Shiba; K Yamauchi; A Harada; I Takamisawa; K Shimokado; K Kataoka
Journal:  Gene Ther       Date:  2002-03       Impact factor: 5.250

8.  Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response.

Authors:  Marie-Elise Bonnet; Patrick Erbacher; Anne-Laure Bolcato-Bellemin
Journal:  Pharm Res       Date:  2008-08-16       Impact factor: 4.200

Review 9.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
Journal:  Nat Nanotechnol       Date:  2007-12       Impact factor: 39.213

Review 10.  Degradable polyethylenimines as DNA and small interfering RNA carriers.

Authors:  D Jere; H L Jiang; R Arote; Y K Kim; Y J Choi; M H Cho; T Akaike; C S Cho
Journal:  Expert Opin Drug Deliv       Date:  2009-08       Impact factor: 6.648
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  3 in total

1.  RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells.

Authors:  Bo Lou; Kate Connor; Kieron Sweeney; Ian S Miller; Alice O'Farrell; Eduardo Ruiz-Hernandez; David M Murray; Garry P Duffy; Alan Wolfe; Enrico Mastrobattista; Annette T Byrne; Wim E Hennink
Journal:  Drug Deliv Transl Res       Date:  2019-06       Impact factor: 4.617

2.  Shape Control in Engineering of Polymeric Nanoparticles for Therapeutic Delivery.

Authors:  John-Michael Williford; Jose Luis Santos; Rishab Shyam; Hai-Quan Mao
Journal:  Biomater Sci       Date:  2015-07       Impact factor: 6.843

3.  Critical Length of PEG Grafts on lPEI/DNA Nanoparticles for Efficient in Vivo Delivery.

Authors:  John-Michael Williford; Maani M Archang; Il Minn; Yong Ren; Mark Wo; John Vandermark; Paul B Fisher; Martin G Pomper; Hai-Quan Mao
Journal:  ACS Biomater Sci Eng       Date:  2016-03-03
  3 in total

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