Literature DB >> 25530711

Dehalogenation of Functionalized Alkyl Halides in Water at Room Temperature.

Nicholas A Isley1, Matt S Hageman1, Bruce H Lipshutz1.   

Abstract

Alkyl bromides and chlorides can be reduced to the corresponding hydrocarbons utilizing zinc in the presence of an amine additive. The process takes place in water at ambient temperatures, enabled by a commercially available designer surfactant. The reaction medium can be readily recycled, and the amount of organic solvent invested for product isolation is minimal, leading to very low E Factors.

Entities:  

Year:  2015        PMID： 25530711      PMCID： PMC4267473          DOI： 10.1039/C4GC01733A

Source DB:  PubMed          Journal:  Green Chem        ISSN： 1463-9262            Impact factor:   10.182


  13 in total

1.  Metal-mediated reductive hydrodehalogenation of organic halides.

Authors:  Francisco Alonso; Irina P Beletskaya; Miguel Yus
Journal:  Chem Rev       Date:  2002-11       Impact factor: 60.622

2.  Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

Authors:  K S Moulton; E Heller; M A Konerding; E Flynn; W Palinski; J Folkman
Journal:  Circulation       Date:  1999-04-06       Impact factor: 29.690

3.  Organozinc Chemistry Enabled by Micellar Catalysis. Palladium-Catalyzed Cross-Couplings between Alkyl and Aryl Bromides in Water at Room Temperature.

Authors:  Christophe Duplais; Arkady Krasovskiy; Bruce H Lipshutz
Journal:  Organometallics       Date:  2011-11-21       Impact factor: 3.876

4.  Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines.

Authors:  M Yamaoka; T Yamamoto; S Ikeyama; K Sudo; T Fujita
Journal:  Cancer Res       Date:  1993-11-01       Impact factor: 12.701

5.  An orally delivered small-molecule formulation with antiangiogenic and anticancer activity.

Authors:  Ofra Benny; Ofer Fainaru; Avner Adini; Flavia Cassiola; Lauren Bazinet; Irit Adini; Elke Pravda; Yaakov Nahmias; Samir Koirala; Gabriel Corfas; Robert J D'Amato; Judah Folkman
Journal:  Nat Biotechnol       Date:  2008-06-29       Impact factor: 54.908

6.  Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents.

Authors:  Arkady Krasovskiy; Christophe Duplais; Bruce H Lipshutz
Journal:  J Am Chem Soc       Date:  2009-11-04       Impact factor: 15.419

Review 7.  On the way towards greener transition-metal-catalyzed processes as quantified by E factors.

Authors:  Bruce H Lipshutz; Nicholas A Isley; James C Fennewald; Eric D Slack
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-12       Impact factor: 15.336

8.  Transforming Suzuki-Miyaura cross-couplings of MIDA boronates into a green technology: no organic solvents.

Authors:  Nicholas A Isley; Fabrice Gallou; Bruce H Lipshutz
Journal:  J Am Chem Soc       Date:  2013-11-13       Impact factor: 15.419

9.  Electron-transfer photoredox catalysis: development of a tin-free reductive dehalogenation reaction.

Authors:  Jagan M R Narayanam; Joseph W Tucker; Corey R J Stephenson
Journal:  J Am Chem Soc       Date:  2009-07-01       Impact factor: 15.419

10.  C-C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature.

Authors:  Bruce H Lipshutz; Shenlin Huang; Wendy Wen Yi Leong; Guofu Zhong; Nicholas A Isley
Journal:  J Am Chem Soc       Date:  2012-11-28       Impact factor: 15.419
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  2 in total

1.  Single-Micelle and Single-Zinc-Particle Imaging Provides Insights into the Physical Processes Underpinning Organozinc Reactions in Water.

Authors:  Hannah Peacock; Suzanne A Blum
Journal:  J Am Chem Soc       Date:  2022-02-14       Impact factor: 15.419

2.  Aspirination of α-Aminoalcohol (Sarpogrelate M1).

Authors:  Sunhwa Park; Jiyun Lee; Kye Jung Shin; Jae Hong Seo
Journal:  Molecules       Date:  2016-08-25       Impact factor: 4.411
  2 in total

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