| Literature DB >> 25530565 |
Carolina Pereira Souza Melo1, Catharina Brant Campos2, Álvaro Pimenta Dutra3, Joaquim Caetano Aguirre Neto4, Alexandre José Silva Fenelon5, Abrahão Hallack Neto6, Edna Kakitani Carbone7, Mara Albonei Dudeque Pianovski8, Alessandro Clayton de Souza Ferreira9, Juliana Godoy Assumpcão10.
Abstract
Internal tandem duplications (ITD) of FLT3 gene occur in about a third of acute promyelocytic leukemias (APL). We investigated the patterns of blood count, surface antigen, expression, chromosome aberrations, PML-RARa isoform, gene expression profile (GEP) and survival in 34 APL patients according to FLT3-ITD status. 97% had a t(15;17) and all of them carried PML-RARa gene fusion, 8 (23.5%) had a FLT3-ITD mutation. Presence of ITD was associated with higher Hb and WBC levels, bcr3 isoform, CD34 expression, CD2 or CD2/CD34 expression. In a multivariate analysis, Hb>9.6g/dL and WBC≥20 × 10(9)/L were important factors for predicting ITD presence. GEP showed that FLT3-ITD carriers clustered separately, even when as few as 5 genes were considered. This study provides further evidence that FLT3-ITDs carriers constitute a biologically distinct group of APL patients.Entities:
Keywords: 17); AML M3; Acute promyelocytic leukemia; FLT3–ITD; PML–RARA; t(15
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Year: 2014 PMID： 25530565 DOI： 10.1016/j.leukres.2014.11.010
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156