Literature DB >> 25530161

Evidence for increasing severity of community-onset boils and abscesses in UK General Practice.

L J Shallcross1, A C Hayward1, A M Johnson1, I Petersen2.   

Abstract

In England, hospital admissions for severe staphylococcal boils and abscesses trebled between 1989 and 2004. We investigated this trend using routine data from primary and secondary care. We used The Health Improvement Network (THIN), a large primary-care database and national data on hospital admissions from Hospital Episode Statistics (HES). Time trends in the incidence of primary-care consultations for boils and abscesses were estimated for 1995-2010. HES data were used to calculate age-standardized hospital admission rates for boils, abscesses and cellulitis. The incidence of boil or abscess was 450 [95% confidence interval (CI) 447-452] per 100 000 person-years and increased slightly over the study period (incidence rate ratio 1·005, 95% CI 1·004-1·007). The rate of repeat consultation for a boil or abscess increased from 66 (95% CI 59-73) per 100 000 person-years in 1995 to peak at 97 (95% CI 94-101) per 100 000 person-years in 2006, remaining stable thereafter. Hospital admissions for abscesses, carbuncles, furuncles and cellulitis almost doubled, from 123 admissions per 100 000 in 1998/1999 to 236 admissions per 100 000 in 2010/2011. Rising hospitalization and recurrence rates set against a background of stable community incidence suggests increased disease severity. Patients may be experiencing more severe and recurrent staphylococcal skin disease with limited treatment options.

Entities:  

Keywords:  Community epidemics; Staphylococcus aureus; epidemiology; incidence; public health

Mesh:

Year:  2014        PMID: 25530161      PMCID: PMC9150931          DOI: 10.1017/S0950268814003458

Source DB:  PubMed          Journal:  Epidemiol Infect        ISSN: 0950-2688            Impact factor:   4.434


  9 in total

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2.  Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research.

Authors:  James D Lewis; Rita Schinnar; Warren B Bilker; Xingmei Wang; Brian L Strom
Journal:  Pharmacoepidemiol Drug Saf       Date:  2007-04       Impact factor: 2.890

3.  Generalisability of The Health Improvement Network (THIN) database: demographics, chronic disease prevalence and mortality rates.

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Journal:  Inform Prim Care       Date:  2011

4.  Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial.

Authors:  Stephanie A Fritz; Bernard C Camins; Kimberly A Eisenstein; Joseph M Fritz; Emma K Epplin; Carey-Ann Burnham; Jonathan Dukes; Gregory A Storch
Journal:  Infect Control Hosp Epidemiol       Date:  2011-09       Impact factor: 3.254

5.  Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease.

Authors:  A Holmes; M Ganner; S McGuane; T L Pitt; B D Cookson; A M Kearns
Journal:  J Clin Microbiol       Date:  2005-05       Impact factor: 5.948

6.  National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections.

Authors:  Adam L Hersh; Henry F Chambers; Judith H Maselli; Ralph Gonzales
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7.  Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin.

Authors:  Philippe Dufour; Yves Gillet; Michèle Bes; Gerard Lina; François Vandenesch; Daniel Floret; Jerome Etienne; Hervé Richet
Journal:  Clin Infect Dis       Date:  2002-09-03       Impact factor: 9.079

8.  The importance of defining periods of complete mortality reporting for research using automated data from primary care.

Authors:  Andrew Maguire; Betina T Blak; Mary Thompson
Journal:  Pharmacoepidemiol Drug Saf       Date:  2009-01       Impact factor: 2.890

9.  Increasing hospitalizations and general practice prescriptions for community-onset staphylococcal disease, England.

Authors:  Andrew Hayward; Felicity Knott; Irene Petersen; David M Livermore; Georgia Duckworth; Amir Islam; Anne M Johnson
Journal:  Emerg Infect Dis       Date:  2008-05       Impact factor: 6.883

  9 in total
  4 in total

1.  Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus.

Authors:  Liana C Chan; Siyang Chaili; Scott G Filler; Lloyd S Miller; Norma V Solis; Huiyuan Wang; Colin W Johnson; Hong K Lee; Luis F Diaz; Michael R Yeaman
Journal:  Infect Immun       Date:  2017-01-26       Impact factor: 3.441

2.  Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.

Authors:  Liana C Chan; Maura Rossetti; Lloyd S Miller; Scott G Filler; Colin W Johnson; Hong K Lee; Huiyuan Wang; David Gjertson; Vance G Fowler; Elaine F Reed; Michael R Yeaman
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-08       Impact factor: 11.205

3.  Interventions for bacterial folliculitis and boils (furuncles and carbuncles).

Authors:  Huang-Shen Lin; Pei-Tzu Lin; Yu-Shiun Tsai; Shu-Hui Wang; Ching-Chi Chi
Journal:  Cochrane Database Syst Rev       Date:  2021-02-26

4.  Incidence and recurrence of boils and abscesses within the first year: a cohort study in UK primary care.

Authors:  Laura J Shallcross; Andrew C Hayward; Anne M Johnson; Irene Petersen
Journal:  Br J Gen Pract       Date:  2015-10       Impact factor: 5.386

  4 in total

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