Literature DB >> 2552996

Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes.

N F Brown1, A M Salter, R Fears, D N Brindley.   

Abstract

Rat hepatocytes were preincubated for 16 h with hormones or drugs and then for a further 8 h with 125I-human low-density lipoprotein (LDL). Glucagon (via cyclic AMP) and adrenaline (via cyclic AMP and alpha-effects) increased the binding of 125I-LDL to the LDL receptor, and the degradation of LDL to [125I]iodotyrosine. The effects on degradation were antagonized by dexamethasone, and the action of cyclic AMP on binding and degradation was inhibited by actinomycin D. The results are discussed in relation to the control of lipoprotein metabolism in diabetes.

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Year:  1989        PMID： 2552996      PMCID： PMC1133285          DOI： 10.1042/bj2620425

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  40 in total

1.  Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

Authors:  P T Kovanen; M S Brown; J L Goldstein
Journal:  J Biol Chem       Date:  1979-11-25       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Indomethacin inhibits the cellular receptor-dependent processing of low density lipoproteins; cyclic nucleotides have no effect.

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Journal:  J Clin Endocrinol Metab       Date:  1980-09       Impact factor: 5.958

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Authors:  P N Durrington; R S Newton; D B Weinstein; D Steinberg
Journal:  J Clin Invest       Date:  1982-07       Impact factor: 14.808

5.  Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by human chorionic gonadotropin, cyclic AMP, and sterol.

Authors:  T G Golos; A M August; J F Strauss
Journal:  J Lipid Res       Date:  1986-10       Impact factor: 5.922

Review 6.  Hyperlipidaemia of diabetes.

Authors:  G F Gibbons
Journal:  Clin Sci (Lond)       Date:  1986-11       Impact factor: 6.124

7.  Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes.

Authors:  C E Sparks; J D Sparks; M Bolognino; A Salhanick; P S Strumph; J M Amatruda
Journal:  Metabolism       Date:  1986-12       Impact factor: 8.694

8.  Lipoprotein secretion by isolated rat hepatocytes: characterization of the lipid-carrying particles and modulation of their release.

Authors:  H J Kempen
Journal:  J Lipid Res       Date:  1980-08       Impact factor: 5.922

9.  Dibutyryl cyclic AMP inhibits LDL binding in cultured fibroblasts and arterial smooth muscle cells.

Authors:  R W Stout; E L Bierman
Journal:  Atherosclerosis       Date:  1983-01       Impact factor: 5.162

10.  Effect of cyclic AMP on low density lipoprotein binding and internalization by cultured human fibroblasts.

Authors:  J C Mazière; C Mazière; J Gardette; L Mora; J Polonovski
Journal:  Biochem Biophys Res Commun       Date:  1983-05-16       Impact factor: 3.575
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  8 in total

1.  Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.

Authors:  E Eliasson; I Johansson; M Ingelman-Sundberg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

2.  Agents which increase cyclic AMP have diverse effects on low-density-lipoprotein-receptor function in human vascular smooth-muscle cells and skin fibroblasts.

Authors:  A Middleton; B Middleton
Journal:  Biochem J       Date:  1990-05-01       Impact factor: 3.857

3.  Biphasic effects of glucagon and cyclic AMP on the synthesis and secretion of lipids by rat hepatocytes.

Authors:  D Hermier; P Hales; D N Brindley
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

4.  Stimulation of low-density lipoprotein uptake in HepG2 cells by epidermal growth factor via a tyrosine kinase-dependent, but protein kinase C-independent, mechanism.

Authors:  A Graham; L J Russell
Journal:  Biochem J       Date:  1994-03-15       Impact factor: 3.857

5.  Cyclic AMP stimulates the synthesis and function of the low-density lipoprotein receptor in human vascular smooth-muscle cells and fibroblasts.

Authors:  B Middleton; A Middleton
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

6.  Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo.

Authors:  M Rudling; B Angelin
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808

7.  Endotoxin suppresses rat hepatic low-density lipoprotein receptor expression.

Authors:  W Liao; M Rudling; B Angelin
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857

8.  Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans.

Authors:  Changting Xiao; Mirjana Pavlic; Linda Szeto; Bruce W Patterson; Gary F Lewis
Journal:  Diabetes       Date:  2010-10-27       Impact factor: 9.461
  8 in total

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