| Literature DB >> 25529736 |
B Narasimhulu Naidu1, Margaret E Sorenson2, Manoj Patel2, Yasutsugu Ueda2, Jacques Banville2, Francis Beaulieu2, Sagarika Bollini3, Ira B Dicker3, Helen Higley3, Zeyu Lin3, Lori Pajor4, Dawn D Parker4, Brian J Terry3, Ming Zheng4, Alain Martel2, Nicholas A Meanwell2, Mark Krystal3, Michael A Walker2.
Abstract
Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.Entities:
Keywords: HIV-1; Inhibitor; Integrase; Pyrimidine-4-carboxamide; Strand transfer
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Year: 2014 PMID： 25529736 DOI： 10.1016/j.bmcl.2014.11.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823