Literature DB >> 25529200

Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors.

James S Martenson1, Susumu Tomita2.   

Abstract

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by localizing at postsynapses. Changes in receptor number at synapses induce synaptic plasticity. Thus, mechanisms for the synaptic localization of receptors in basal transmission and synaptic plasticity have been investigated extensively. Recent findings reveal that synaptic localization of tetrameric AMPA receptors in basal transmission requires the PDZ binding of TARP auxiliary subunits, which modulate receptor properties and pharmacology. On the other hand, pentameric GABAA receptors require multiple receptor subunits for their synaptic localization in basal transmission. AMPA receptors seem to utilize distinct mechanisms for basal synaptic localization and synaptic insertion during plasticity. Revealing precise mechanisms for receptor synaptic localization may establish new approaches to control synaptic transmission.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25529200      PMCID： PMC4318715          DOI： 10.1016/j.coph.2014.11.011

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  64 in total

1.  A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.

Authors:  Roland Baur; Frédéric Minier; Erwin Sigel
Journal:  FEBS Lett       Date:  2006-02-17       Impact factor: 4.124

2.  AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform.

Authors:  Martin B Gill; Akihiko S Kato; He Wang; David S Bredt
Journal:  Eur J Neurosci       Date:  2011-12-30       Impact factor: 3.386

3.  Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.

Authors:  G E Homanics; T M DeLorey; L L Firestone; J J Quinlan; A Handforth; N L Harrison; M D Krasowski; C E Rick; E R Korpi; R Mäkelä; M H Brilliant; N Hagiwara; C Ferguson; K Snyder; R W Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

4.  Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.

Authors:  D Zamanillo; R Sprengel; O Hvalby; V Jensen; N Burnashev; A Rozov; K M Kaiser; H J Köster; T Borchardt; P Worley; J Lübke; M Frotscher; P H Kelly; B Sommer; P Andersen; P H Seeburg; B Sakmann
Journal:  Science       Date:  1999-06-11       Impact factor: 47.728

5.  Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin.

Authors:  C Essrich; M Lorez; J A Benson; J M Fritschy; B Lüscher
Journal:  Nat Neurosci       Date:  1998-11       Impact factor: 24.884

6.  Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice.

Authors:  Remo Studer; Lotta von Boehmer; Tatjana Haenggi; Claude Schweizer; Dietmar Benke; Uwe Rudolph; Jean-Marc Fritschy
Journal:  Eur J Neurosci       Date:  2006-09       Impact factor: 3.386

7.  Functional properties of recombinant rat GABAA receptors depend upon subunit composition.

Authors:  T A Verdoorn; A Draguhn; S Ymer; P H Seeburg; B Sakmann
Journal:  Neuron       Date:  1990-06       Impact factor: 17.173

8.  Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Authors:  U Günther; J Benson; D Benke; J M Fritschy; G Reyes; F Knoflach; F Crestani; A Aguzzi; M Arigoni; Y Lang; H Bluethmann; H Mohler; B Lüscher
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.

Authors:  M Migaud; P Charlesworth; M Dempster; L C Webster; A M Watabe; M Makhinson; Y He; M F Ramsay; R G Morris; J H Morrison; T J O'Dell; S G Grant
Journal:  Nature       Date:  1998-12-03       Impact factor: 49.962

10.  Colocalization of gephyrin and GABAA-receptor subunits in the rat retina.

Authors:  M Sassoè-Pognetto; J Kirsch; U Grünert; U Greferath; J M Fritschy; H Möhler; H Betz; H Wässle
Journal:  J Comp Neurol       Date:  1995-06-19       Impact factor: 3.215
View more
  4 in total

1.  Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome.

Authors:  Verónica Vidal; Susana García-Cerro; Paula Martínez; Andrea Corrales; Sara Lantigua; Rebeca Vidal; Noemí Rueda; Laurence Ozmen; Maria-Clemencia Hernández; Carmen Martínez-Cué
Journal:  Mol Neurobiol       Date:  2017-07-17       Impact factor: 5.590

2.  Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation.

Authors:  Rikki Hullinger; Mi Li; Jingxin Wang; Yajing Peng; James A Dowell; Ewa Bomba-Warczak; Heather A Mitchell; Corinna Burger; Edwin R Chapman; John M Denu; Lingjun Li; Luigi Puglielli
Journal:  J Exp Med       Date:  2016-05-30       Impact factor: 14.307

3.  Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo.

Authors:  Taisuke Miyazaki; Megumi Morimoto-Tomita; Coralie Berthoux; Kotaro Konno; Yoav Noam; Tokiwa Yamasaki; Matthijs Verhage; Pablo E Castillo; Masahiko Watanabe; Susumu Tomita
Journal:  Elife       Date:  2021-10-18       Impact factor: 8.140

4.  The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory.

Authors:  Leanne J M Schmitz; Remco V Klaassen; Marta Ruiperez-Alonso; Huib D Mansvelder; August B Smit; Sabine Spijker; Azra Elia Zamri; Jasper Stroeder; Priyanka Rao-Ruiz; Johannes C Lodder; Rolinka J van der Loo
Journal:  Elife       Date:  2017-12-04       Impact factor: 8.140
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.