K Berganzo1, B Tijero2, A González-Eizaguirre2, J Somme3, E Lezcano2, I Gabilondo2, M Fernandez2, J J Zarranz2, J C Gómez-Esteban2. 1. Grupo Enfermedades Neurodegenerativas, Unidad de trastornos del movimiento y disautonomía, BioCruces Health Research Institute, Barakaldo, Bizkaia, España. Electronic address: koldo_ber@hotmail.com. 2. Grupo Enfermedades Neurodegenerativas, Unidad de trastornos del movimiento y disautonomía, BioCruces Health Research Institute, Barakaldo, Bizkaia, España. 3. Servicio de Neurología, Hospital Universitario Álava, Vitoria-Gasteiz, España.
Abstract
INTRODUCTION: The aim of the present study is to analyse the influence that motor and non-motor symptoms have on the quality of life (QoL) of patients with Parkinson's disease (PD), and to study the relationship between the two types of symptoms. MATERIAL AND METHODS: This cross-sectional study included 103 patients with PD (55 men and 48 women). Quality of life was measured on the PDQ-39 scale. The UPDRS scale (I-IV) was also used, and different items were grouped to analyse the presence of tremor, rigidity, bradykinesia, and axial symptoms. The non-motor symptoms scale (NMSS) was administered to assess non-motor symptoms. We performed correlation analyses between different scales to analyse the influence of motor and non-motor symptoms on QoL. RESULTS: Correlations were observed between the PDQ-39 summary index (PDQ39_SI) and the NMSS (correlation coefficient [cc], 0.56; p<.001), UPDRS III (cc, 0.44; p< .001) and UPDRS IV (cc, 0.37; p<.001) scores. The strongest correlation was between cognitive symptoms and mood. The analysis pointed to a direct relationship between the NMSS score and axial symptoms (cc, 0.384; p<.01), bradykinesia (cc, 0.299; p<.01), and to a lesser extent, rigidity (cc, 0.194; p<.05). No relationship was observed between presence of tremor and the NMSS score. CONCLUSION: Cognitive symptoms and mood exert the most influence on QoL of patients with PD. We found at least two phenotypes; one with predominantly axial symptoms, with significant involvement of non-motor symptoms, and a tremor-associated phenotype in which these symptoms are less prevalent.
INTRODUCTION: The aim of the present study is to analyse the influence that motor and non-motor symptoms have on the quality of life (QoL) of patients with Parkinson's disease (PD), and to study the relationship between the two types of symptoms. MATERIAL AND METHODS: This cross-sectional study included 103 patients with PD (55 men and 48 women). Quality of life was measured on the PDQ-39 scale. The UPDRS scale (I-IV) was also used, and different items were grouped to analyse the presence of tremor, rigidity, bradykinesia, and axial symptoms. The non-motor symptoms scale (NMSS) was administered to assess non-motor symptoms. We performed correlation analyses between different scales to analyse the influence of motor and non-motor symptoms on QoL. RESULTS: Correlations were observed between the PDQ-39 summary index (PDQ39_SI) and the NMSS (correlation coefficient [cc], 0.56; p<.001), UPDRS III (cc, 0.44; p< .001) and UPDRS IV (cc, 0.37; p<.001) scores. The strongest correlation was between cognitive symptoms and mood. The analysis pointed to a direct relationship between the NMSS score and axial symptoms (cc, 0.384; p<.01), bradykinesia (cc, 0.299; p<.01), and to a lesser extent, rigidity (cc, 0.194; p<.05). No relationship was observed between presence of tremor and the NMSS score. CONCLUSION:Cognitive symptoms and mood exert the most influence on QoL of patients with PD. We found at least two phenotypes; one with predominantly axial symptoms, with significant involvement of non-motor symptoms, and a tremor-associated phenotype in which these symptoms are less prevalent.
Authors: Alberto J Espay; Paolo Bonato; Fatta B Nahab; Walter Maetzler; John M Dean; Jochen Klucken; Bjoern M Eskofier; Aristide Merola; Fay Horak; Anthony E Lang; Ralf Reilmann; Joe Giuffrida; Alice Nieuwboer; Malcolm Horne; Max A Little; Irene Litvan; Tanya Simuni; E Ray Dorsey; Michelle A Burack; Ken Kubota; Anita Kamondi; Catarina Godinho; Jean-Francois Daneault; Georgia Mitsi; Lothar Krinke; Jeffery M Hausdorff; Bastiaan R Bloem; Spyros Papapetropoulos Journal: Mov Disord Date: 2016-04-29 Impact factor: 10.338