| Literature DB >> 2552915 |
K Fukuchi1, H Sakagami, T Okuda, T Hatano, S Tanuma, K Kitajima, Y Inoue, S Inoue, S Ichikawa, M Nonoyama.
Abstract
Several chemically defined plant extracts were investigated for their antiviral action on herpes simplex virus (HSV-1, HSV-2)-infected African green monkey kidney cells and human adenocarcinoma cells, using a plaque formation assay. Among them, the monomeric hydrolyzable tannins, oligomeric ellagitannins and condensed tannins, having galloyl groups or hexahydroxydiphenoyl groups, had the most potent anti-HSV activity. Their 50% effective doses (0.03-0.1 microgram/ml) were by two-three orders of magnitude lower than their 50% cytotoxic doses (greater than 10 micrograms/ml). On the other hand, gallic acid, neutral polysaccharides, chemically modified (N,N-dimethylaminoethyl-, carboxymethyl-, and sulfated-) glucans, sialic acid-rich glycoproteins, and uronic acid-rich pine cone polysaccharide showed little or no activity. Using radiolabeled virus particles, we demonstrated that the anti-HSV effect of the tannins is due to inhibition of virus adsorption to the cells.Entities:
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Year: 1989 PMID： 2552915 DOI： 10.1016/0166-3542(89)90038-7
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970