| Literature DB >> 25529136 |
Mark A Chapman1, Rajeswari Pichika2, Richard L Lieber3.
Abstract
Skeletal muscle fibrosis is characterized by increases in tissue stiffness and collagen content. However, a very weak correlation exists between collagen content and stiffness in skeletal muscle. Recently, it has been hypothesized that collagen crosslinking explains tissue stiffness in fibrotic skeletal muscle. Therefore, we addressed this hypothesis by correlating tissue stiffness with lysyl-pyridinoline, hydroxylysyl-pyridinoline, and pentosidine collagen crosslinks. Stepwise regression revealed that, separate or together, collagen crosslinks did not correlate with tissue stiffness. Our result demonstrates that increased tissue stiffness in skeletal muscle fibrosis is not simply explained by increased collagen crosslinks and/or collagen crosslink density. We suggest that collagen organization may affect tissue stiffness. Published by Elsevier Ltd.Entities:
Keywords: Collagen crosslinking; Extracellular matrix; Fibrosis; Mechanical properties; Muscle
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Year: 2014 PMID： 25529136 PMCID： PMC4286487 DOI： 10.1016/j.jbiomech.2014.12.005
Source DB: PubMed Journal: J Biomech ISSN： 0021-9290 Impact factor: 2.712