Literature DB >> 2552913

Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus.

F Superti1, L Seganti, N Orsi, M Divizia, R Gabrieli, A Panà, M L Stein.   

Abstract

The effect of 6,4'-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0 degrees C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4'-dichloroflavan and 6,4'-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.

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Year:  1989        PMID： 2552913     DOI： 10.1016/0166-3542(89)90034-x

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  7 in total

1.  Activities and mechanisms of action of halogen-substituted flavanoids against poliovirus type 2 infection in vitro.

Authors:  C Conti; D Genovese; R Santoro; M L Stein; N Orsi; L Fiore
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

2.  Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirus.

Authors:  Anna L Salvati; Alessandra De Dominicis; Sabrina Tait; Andrea Canitano; Armin Lahm; Lucia Fiore
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

3.  Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan.

Authors:  C Conti; P Tomao; D Genovese; N Desideri; M L Stein; N Orsi
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

4.  Antiviral activity of 3(2H)- and 6-chloro-3(2H)-isoflavenes against highly diverged, neurovirulent vaccine-derived, type2 poliovirus sewage isolates.

Authors:  Lester M Shulman; Danit Sofer; Yossi Manor; Ella Mendelson; Jean Balanant; Anna Laura Salvati; Francis Delpeyroux; Lucia Fiore
Journal:  PLoS One       Date:  2011-05-25       Impact factor: 3.240

5.  Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors.

Authors:  Wei Zhang; Haishi Qiao; Yuanzi Lv; Jingjing Wang; Xiaoqing Chen; Yayi Hou; Renxiang Tan; Erguang Li
Journal:  PLoS One       Date:  2014-10-16       Impact factor: 3.240

Review 6.  Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus.

Authors:  Tatsuo Kanda; Shingo Nakamoto; Shuang Wu; Masato Nakamura; Xia Jiang; Yuki Haga; Reina Sasaki; Osamu Yokosuka
Journal:  J Clin Transl Hepatol       Date:  2015-09-15

Review 7.  Molecular biology and inhibitors of hepatitis A virus.

Authors:  Yannick Debing; Johan Neyts; Hendrik Jan Thibaut
Journal:  Med Res Rev       Date:  2013-05-30       Impact factor: 12.944
  7 in total

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