| Literature DB >> 25528858 |
Celso O Rezende1, Larissa A Oliveira1, Bruno A Oliveira1, Camila G Almeida1, Bianca S Ferreira1, Mireille Le Hyaric1, Guilherme S L Carvalho2, Maria Cristina S Lourenço2, Michel Batista3, Fabricio K Marchini3, Vânia L Silva4, Claudio G Diniz4, Mauro V Almeida1.
Abstract
Different series of N-alkylated diamines and their derivatives condensed to quinic acid were synthesized and tested for antibacterial properties against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The lipophilic chain and carbohydrate moiety modulate the antibacterial activity and the compounds showed a structure-activity relationship. Overall, 11 compounds displayed better activity than chloramphenicol against Gram-positive and Gram-negative bacteria. Monoalkylated amines 2a-h displayed an activity similar to that of ethambutol against Mycobacterium tuberculosis.Entities:
Keywords: antibacterial; diamines; lipophilicity; quinic acid; tuberculosis
Mesh：
Substances：
Year: 2015 PMID： 25528858 DOI： 10.1111/cbdd.12498
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817