Literature DB >> 2552850

Visceral leishmaniasis unresponsive to pentostam caused by Leishmania tropica in Kenya.

Y Mebrahtu1, P Lawyer, J Githure, J B Were, R Muigai, L Hendricks, J Leeuwenburg, D Koech, C Roberts.   

Abstract

We report the characterization of 6 Leishmania tropica isolates from 2 patients with visceral leishmaniasis who were unresponsive to treatment with sodium stibogluconate. The Leishmania isolates, MHOM/KE/81/NLB-029A, -029XIB, and -029XIC and MHOM/KE/81/NLB-030I, -030B, and -030XXA, all from splenic aspirates, were characterized by cellulose acetate electrophoresis using 11 enzymes: malate dehydrogenase, malic enzyme, phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutamate-oxaloacetate transaminase, adenylate kinase, nucleoside hydrolase, mannose phosphate isomerase, glucose phosphate isomerase, and phosphoglucomutase. Isozyme migration patterns were indistinguishable from those of 2 WHO reference strains of Leishmania tropica (MHOM/SU/60/LRC-L39, NLB-305 and MHOM/IQ/OO/LRC-L36, NLB-067). These are the first reported cases of visceral leishmaniasis (kala-azar) caused by L. tropica in Africa; these cases were refractory to sodium stibogluconate.

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Year:  1989        PMID： 2552850     DOI： 10.4269/ajtmh.1989.41.289

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  16 in total

1.  An axenic amastigote system for drug screening.

Authors:  H L Callahan; A C Portal; R Devereaux; M Grogl
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

2.  Diagnostic and prognostic potential of a competitive enzyme-linked immunosorbent assay for leishmaniasis in India.

Authors:  M Chatterjee; C L Jaffe; S Sundar; D Basu; S Sen; C Mandal
Journal:  Clin Diagn Lab Immunol       Date:  1999-07

3.  Characterization of the recent clinical isolates of Indian Kala-azar patients by RAPD-PCR method.

Authors:  Supriya Khanra; Subir K Bandopadhyay; Priyanka Chakraborty; Sanchita Datta; Dinesh Mondal; Mitali Chatterjee; Khudiram Naskar; Syamal Roy; Madhumita Manna
Journal:  J Parasit Dis       Date:  2011-06-24

4.  Concomitant natural infection with L. donovani and L. major: a case report from Iraq.

Authors:  L J al-Diwany; N A al-Awkati; M Atia; M B Rassam
Journal:  Soz Praventivmed       Date:  1995

5.  Characterization of a Leishmania tropica antigen that detects immune responses in Desert Storm viscerotropic leishmaniasis patients.

Authors:  D C Dillon; C H Day; J A Whittle; A J Magill; S G Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

6.  Viscerotropic growth pattern of Leishmania tropica in BALB/c mice is suggestive of a murine model for human viscerotropic leishmaniasis.

Authors:  Hamid Mahmoudzadeh-Niknam; Simin Sadat Kiaei; Davood Iravani
Journal:  Korean J Parasitol       Date:  2007-12       Impact factor: 1.341

Review 7.  Leishmaniases of the New World: current concepts and implications for future research.

Authors:  G Grimaldi; R B Tesh
Journal:  Clin Microbiol Rev       Date:  1993-07       Impact factor: 26.132

8.  Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent.

Authors:  Mary Ann McDowell; Mary Marovich; Rosalia Lira; Michael Braun; David Sacks
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441

9.  Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.

Authors:  M Ephros; A Bitnun; P Shaked; E Waldman; D Zilberstein
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

10.  Comparative study of viscerotropic pathogenicity of Leishmania major amastigotes and promastigotes based on identification of mitochondrial and nucleus sequences.

Authors:  Adel Spotin; Parviz Parvizi
Journal:  Parasitol Res       Date:  2015-12-03       Impact factor: 2.289
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