| Literature DB >> 25528443 |
Yongtao Gao1, Te Liu2, Yongyi Huang3.
Abstract
We aimed to ascertain the role of microRNAs (miRNAs) in regulating human endometrial cancer stem cells (HuECSCs). The expression level of miRNA-134 (miR-134), a member of the DLK1-DIO3 genomic imprinted miRNA cluster, differed significantly between HuECSCs and human endometrial cancer cells (HuECCs). miR-134 inhibited HuECSCs proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression. Exogenous miR-134 overexpression downregulated POGLUT1 and Notch pathway proteins in HuECSCs in vitro. miR-134 overexpression affected the G2/M phase of HuECSCs and suppressed the growth of xenograft tumours formed. Thus, endogenous miR-134 regulation in HuECSCs may suppress tumourigenesis in human endometrial carcinoma.Entities:
Keywords: DLK1-DIO3 genomic imprinted microRNA cluster; Human endometrial cancer stem cell; MicroRNA-134; Migration; Notch pathway; Proliferation; Protein O-glucosyltransferase 1
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Year: 2014 PMID： 25528443 DOI： 10.1016/j.febslet.2014.12.002
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124