| Literature DB >> 25528080 |
C Daluwatte1, J H Miles2, J Sun3, G Yao4.
Abstract
Atypical pupillary light reflexes (PLR) has been observed in children with autism spectrum disorders (ASD), which suggests potential autonomic nervous system (ANS) dysfunction in ASD. ANS is also involved in modulating sensory processing and sensory dysfunction has been widely reported in children with ASD. However, the potential association between physiological measurements of PLR and behavioral observations (e.g. sensory behaviors) has not been examined extensively in literature. In this study, we investigated the potential correlation between PLR and frequently observed sensory behaviors in children with ASD. We found a significant association between PLR constriction amplitude and a set of sensory behaviors in the ASD group but not in typically developing children. Children with ASD who showed more atypical sensory behaviors also had smaller PLR constriction amplitudes. A smaller PLR constriction amplitude suggests lower parasympathetic modulation. This observation implies that some atypical sensory behaviors in children with ASD could be associated with decreased parasympathetic modulation.Entities:
Keywords: Autism; Autonomic nervous system; Pupillary light reflex; Sensory
Mesh：
Year: 2014 PMID： 25528080 PMCID： PMC4314503 DOI： 10.1016/j.ridd.2014.11.019
Source DB: PubMed Journal: Res Dev Disabil ISSN： 0891-4222