Literature DB >> 2552767

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils.

P E Poubelle1, S Bourgoin, P H Naccache, P Borgeat.   

Abstract

Normal human blood neutrophils were studied for their capacity to synthesize leukotriene B4 (LTB4) and its omega-oxidized metabolites after phagocytosis of zymosan. Phagocytosis of serum-opsonized particles led to a higher release of LTs than did unopsonized zymosan. The most striking effect of phagocytosis was observed when neutrophils were primed with granulocyte-macrophage colony-stimulating factor (GM-CSF): opsonization and GM-CSF synergistically increased LTB4 synthesis by neutrophils.

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Year:  1989        PMID： 2552767     DOI： 10.1007/BF01972830

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Monosodium urate and calcium pyrophosphate crystals differentially activate the excitation-response coupling sequence of human neutrophils.

Authors:  P E Poubelle; R De Medicis; P H Naccache
Journal:  Biochem Biophys Res Commun       Date:  1987-12-16       Impact factor: 3.575

2.  Effects of immune complexes, zymosan preparations and ionophore A 23187 on leukotriene formation in human leukocytes.

Authors:  B Odlander; J A Lindgren; H E Claesson
Journal:  Prostaglandins       Date:  1987-10

3.  Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP.

Authors:  H E Claesson; U Lundberg; C Malmsten
Journal:  Biochem Biophys Res Commun       Date:  1981-04-30       Impact factor: 3.575

4.  Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.

Authors:  O H Nielsen; J Elmgreen; B S Thomsen; I Ahnfelt-Rønne; A Wiik
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

5.  The detection and initial characterization of colony-stimulating factors in synovial fluid.

Authors:  D J Williamson; C G Begley; M A Vadas; D Metcalf
Journal:  Clin Exp Immunol       Date:  1988-04       Impact factor: 4.330

6.  Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils.

Authors:  J Fleischmann; D W Golde; R H Weisbart; J C Gasson
Journal:  Blood       Date:  1986-09       Impact factor: 22.113

7.  Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals.

Authors:  C A Dahinden; J Zingg; F E Maly; A L de Weck
Journal:  J Exp Med       Date:  1988-04-01       Impact factor: 14.307

8.  Opsonized bacteria stimulate leukotriene synthesis in human leukocytes.

Authors:  H E Claesson; J A Lindgren; B Gustafsson
Journal:  Biochim Biophys Acta       Date:  1985-10-02
  8 in total
  5 in total

1.  Recombinant Granulocyte-Macrophage Colony-Stimulating Factor (rGM-CSF) : A Review of its Pharmacological Properties and Prospective Role in the Management of Myelosuppression.

Authors:  Susan M Grant; Rennie C Heel
Journal:  Drugs       Date:  1992-04       Impact factor: 9.546

2.  Involvement of leukotriene B4 and platelet-activating factor in cytokine priming of human polymorphonuclear leucocytes.

Authors:  A G Stewart; T Harris; M De Nichilo; A F Lopez
Journal:  Immunology       Date:  1991-02       Impact factor: 7.397

3.  Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.

Authors:  P P McDonald; S R McColl; P Braquet; P Borgeat
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

4.  Granulocyte and granulocyte-macrophage colony-stimulating factors exert differential effects on neutrophil platelet-activating factor generation and release.

Authors:  A G Stewart; T Cotterill; T Harris
Journal:  Immunology       Date:  1994-05       Impact factor: 7.397

5.  Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

Authors:  S Bourgoin; E Plante; M Gaudry; P H Naccache; P Borgeat; P E Poubelle
Journal:  J Exp Med       Date:  1990-09-01       Impact factor: 14.307
  5 in total

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