Literature DB >> 2552760

Modulation of IL-1-induced collagenase production in articular chondrocytes by pertussis toxin.

A Crawford1, M J Crossley.   

Abstract

The effects of pertussis and cholera toxins on interleukin-1 (IL-1) stimulated collagenase production from rabbit articular chondrocytes were investigated. Cholera toxin (50-1000 ng/ml) had no significant effect on IL-1-stimulated collagenase production. Pertussis toxin gave a 50-100% inhibition of collagenase activity induced by submaximal IL-1 concentrations. However, pertussis toxin had little effect on collagenase activity induced by maximal concentrations of IL-1. Optimal inhibitory effects were observed with 5-10 ng/ml of toxin.

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Year:  1989        PMID： 2552760     DOI： 10.1007/BF01972786

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen.

Authors:  T E Cawston; A J Barrett
Journal:  Anal Biochem       Date:  1979-11-01       Impact factor: 3.365

Review 2.  G proteins: transducers of receptor-generated signals.

Authors:  A G Gilman
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

3.  ADP-ribosylation of the inhibitory guanine nucleotide regulatory protein (Ni) as a possible mechanism underlying development of beta-adrenergic responses during primary culture of rat hepatocytes.

Authors:  M Ui; F Okajima; H Itoh
Journal:  Adv Cyclic Nucleotide Protein Phosphorylation Res       Date:  1985

4.  Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator.

Authors:  J E Meats; M B McGuire; R G Russell
Journal:  Nature       Date:  1980-08-28       Impact factor: 49.962

5.  A direct simultaneous plate assay of proteoglycan and collagen degradation by cells in culture and its application to synovial cells.

Authors:  C Peeters-Joris; X Emonds-Alt; G Vaes
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

6.  There is more than one interleukin 1.

Authors:  J J Oppenheim; E J Kovacs; K Matsushima; S K Durum
Journal:  Immunol Today       Date:  1986-02

7.  Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.

Authors:  C Jacquemin; H Thibout; B Lambert; C Correze
Journal:  Nature       Date:  1986 Sep 11-17       Impact factor: 49.962

Review 8.  ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins.

Authors:  J Moss; M Vaughan
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1988
  8 in total

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