| Literature DB >> 25527180 |
Christian Wernli1, Jost Eikenberg2, Olaf Marzocchi3, Bastian Breustedt3, Ursula Oestreicher4, Horst Romm4, Demetrio Gregoratto5, James Marsh5.
Abstract
In 1983, a young man inhaled accidentally a large amount of plutonium and americium. This case was carefully followed until 2013. Since no decorporation measures had been taken, the undisturbed metabolism of Pu and Am can be derived from the data. First objective was to determine the amount of inhaled radionuclides and to estimate committed effective dose. In vivo and excretion measurements started immediately after the inhalation, and for quality assurance, all types of measurements were performed by different labs in Europe and the USA. After dose assessment by various international groups were completed, the measurements were continued to produce scientific data for model validation. The data have been analysed here to estimate lung absorption parameter values for the inhaled plutonium and americium oxide using the proposed new ICRP Human Respiratory Tract Model. As supplement to the biokinetic modelling, biological data from three different cytogenetic markers have been added. The estimated committed effective dose is in the order of 1 Sv. The subject is 30 y after the inhalation, of good health, according to a recent medical check-up.Entities:
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Year: 2014 PMID: 25527180 DOI: 10.1093/rpd/ncu342
Source DB: PubMed Journal: Radiat Prot Dosimetry ISSN: 0144-8420 Impact factor: 0.972