| Literature DB >> 2552665 |
N Shimizu1, S Sakuma, Y Ono, K Takada.
Abstract
We studied the regulatory region of the open reading frame BHRF1 of Epstein-Barr virus (EBV) DNA that was responsive to two trans-activators (Z and R) encoded by the BZLF1 and BRLF1, respectively. The 200-bp sequence, nucleotide numbers 53,617 to 53,817 on the EBV map, was sufficient for conferring responsiveness to Z and R. This 200-bp sequence also enhanced expression of the chloramphenicol acetyltransferase (CAT) gene from the simian virus 40 promoter in response to both Z and R, even when inserted downstream of the cat gene. The results indicate that the Z and R response sequence upstream of the BHRF1 has the properties of an enhancer.Entities:
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Year: 1989 PMID： 2552665 DOI： 10.1016/0042-6822(89)90210-9
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616