Literature DB >> 25526223

Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70.

Y Wang1, S R McAlpine.   

Abstract

Both heat shock protein 90 and 70 (Hsp90, Hsp70) are cytoprotective proteins that regulate cell death by stabilizing and folding proteins. Taking a two-pronged approach, involving simultaneous inhibition of Hsp90 and Hsp70, leads to synergistic cell death, which makes this is an appealing clinical therapy.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25526223     DOI： 10.1039/c4ob02531h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  5 in total

1.  Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.

Authors:  Ranjit K Mehta; Sanjima Pal; Koushik Kondapi; Merna Sitto; Cuyler Dewar; Theresa Devasia; Matthew J Schipper; Dafydd G Thomas; Venkatesha Basrur; Manjunath P Pai; Yoshihiro Morishima; Yoichi Osawa; William B Pratt; Theodore S Lawrence; Mukesh K Nyati
Journal:  Clin Cancer Res       Date:  2020-07-27       Impact factor: 12.531

Review 2.  Targeting Hsp70: A possible therapy for cancer.

Authors:  Sanjay Kumar; James Stokes; Udai P Singh; Karyn Scissum Gunn; Arbind Acharya; Upender Manne; Manoj Mishra
Journal:  Cancer Lett       Date:  2016-02-17       Impact factor: 8.679

3.  Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.

Authors:  Jeanette R McConnell; H Jane Dyson; Shelli R McAlpine
Journal:  RSC Med Chem       Date:  2021-02-15

4.  Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.

Authors:  Shu-Fu Lin; Jen-Der Lin; Chuen Hsueh; Ting-Chao Chou; Chun-Nan Yeh; Ming-Huang Chen; Richard J Wong
Journal:  Oncotarget       Date:  2017-06-20

5.  Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines.

Authors:  Francisco Clemente-Vicario; Carlos E Alvarez; Jennie L Rowell; Satavisha Roy; Cheryl A London; William C Kisseberth; Gwendolen Lorch
Journal:  PLoS One       Date:  2015-11-11       Impact factor: 3.240
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.