Literature DB >> 25525981

The identification of three novel biomarkers of major adverse kidney events.

Michael Haase1, Rinaldo Bellomo, Christian Albert, Gregoire Vanpoucke, Griet Thomas, Wouter Laroy, Katleen Verleysen, Siegfried Kropf, Hermann Kuppe, Roland Hetzer, Anja Haase-Fielitz.   

Abstract

AIM: To describe the prognostic value of three novel biomarkers for acute adverse kidney events compared with routine biological markers. MATERIAL &
METHODS: We used high-end MS to quantify biomarkers predictive of acute kidney injury (AKI) and major adverse kidney events (MAKE) in 100 adult patients after open heart surgery (n = 100).
RESULTS: Early postoperatively measured LG3 (a C-terminal fragment of perlecan), LTBP2 (latent transforming growth factor binding protein-2), Cathepsin L as well as two other renal biomarkers (NGAL, Cystatin C) had greater predictive value for AKI (n = 23) and MAKE (n = 24) compared with creatinine, urea and urine output.
CONCLUSIONS: LG3, LTBP2 and Cathepsin L deserve further exploration as biomarkers for the early identification of patients at risk of MAKE.

Entities:  

Keywords:  C-terminal fragment of perlecan; LG3; LTBP2; MAKE; NGAL; cathepsin L; creatinine; cystatin C; latent transforming growth factor binding protein-2; major adverse kidney event; neutrophil gelatinase-associated lipocalin; urea; urine output

Mesh：

Substances：

Year:  2014        PMID： 25525981     DOI： 10.2217/bmm.14.90

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  13 in total

1.  An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.

Authors:  Ben Roediger; Quintin Lee; Shweta Tikoo; Joanna C A Cobbin; James M Henderson; Mika Jormakka; Matthew B O'Rourke; Matthew P Padula; Natalia Pinello; Marisa Henry; Maria Wynne; Sara F Santagostino; Cory F Brayton; Lorna Rasmussen; Leszek Lisowski; Szun S Tay; David C Harris; John F Bertram; John P Dowling; Patrick Bertolino; Jack H Lai; Wengen Wu; William W Bachovchin; Justin J-L Wong; Mark D Gorrell; Babak Shaban; Edward C Holmes; Christopher J Jolly; Sébastien Monette; Wolfgang Weninger
Journal:  Cell       Date:  2018-09-13       Impact factor: 41.582

Review 2.  The Emerging Importance of Non-HLA Autoantibodies in Kidney Transplant Complications.

Authors:  Héloise Cardinal; Mélanie Dieudé; Marie-Josée Hébert
Journal:  J Am Soc Nephrol       Date:  2016-10-17       Impact factor: 10.121

3.  Single-Nucleus Transcriptional Profiling of Chronic Kidney Disease after Cisplatin Nephrotoxicity.

Authors:  Zhengwei Ma; Xiaoru Hu; Han-Fei Ding; Ming Zhang; Yuqing Huo; Zheng Dong
Journal:  Am J Pathol       Date:  2022-01-31       Impact factor: 4.307

4.  Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery.

Authors:  Christian Albert; Annemarie Albert; Rinaldo Bellomo; Siegfried Kropf; Prasad Devarajan; Sabine Westphal; Hassina Baraki; Ingo Kutschka; Christian Butter; Michael Haase; Anja Haase-Fielitz
Journal:  Biomark Med       Date:  2018-08-08       Impact factor: 2.851

5.  Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.

Authors:  Miriam Brazzelli; Lorna Aucott; Magaly Aceves-Martins; Clare Robertson; Elisabet Jacobsen; Mari Imamura; Amudha Poobalan; Paul Manson; Graham Scotland; Callum Kaye; Simon Sawhney; Dwayne Boyers
Journal:  Health Technol Assess       Date:  2022-01       Impact factor: 4.106

Review 6.  The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease.

Authors:  Pasquale Cocchiaro; Valeria De Pasquale; Rossella Della Morte; Simona Tafuri; Luigi Avallone; Anne Pizard; Anna Moles; Luigi Michele Pavone
Journal:  Front Cell Dev Biol       Date:  2017-12-19

7.  Identification of Major Adverse Kidney Events Within the Electronic Health Record.

Authors:  Matthew W Semler; Todd W Rice; Andrew D Shaw; Edward D Siew; Wesley H Self; Avinash B Kumar; Daniel W Byrne; Jesse M Ehrenfeld; Jonathan P Wanderer
Journal:  J Med Syst       Date:  2016-05-27       Impact factor: 4.460

8.  A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus).

Authors:  Markus H Kuehn; Koren A Lipsett; Marilyn Menotti-Raymond; S Scott Whitmore; Todd E Scheetz; Victor A David; Stephen J O'Brien; Zhongyuan Zhao; Jackie K Jens; Elizabeth M Snella; N Matthew Ellinwood; Gillian J McLellan
Journal:  PLoS One       Date:  2016-05-05       Impact factor: 3.240

9.  The Reliability of the Use of Serum Neutrophil Gelatinase-Associated Lipocalin Levels in the Assessment of Renal Functions after Coronary Artery Bypass Grafting.

Authors:  Ozan Onur Balkanay; Deniz Göksedef; Suat Nail Ömeroğlu; Gökhan İpek
Journal:  Cardiol Res Pract       Date:  2018-03-05       Impact factor: 1.866

10.  Post-contrast acute kidney injury in a hospitalized population: short-, mid-, and long-term outcome and risk factors for adverse events.

Authors:  Wei Cheng; Xi Wu; Qian Liu; Hong-Shen Wang; Ning-Ya Zhang; Ye-Qing Xiao; Ping Yan; Xu-Wei Li; Xiang-Jie Duan; Jing-Cheng Peng; Song Feng; Shao-Bin Duan
Journal:  Eur Radiol       Date:  2020-02-21       Impact factor: 5.315
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