Literature DB >> 25525588

Massive alveolar haemorrhage: a rare life threatening complication of Wegener's granulomatosis-report of a rare case.

Richa Arora1.   

Abstract

Massive diffuse alveolar haemorrhage (DAH) is an unusual, frequently life threatening and still treatable complication of Wegener's granulomatosis (WG) associated with mortality in more than 66% of cases. DAH is a syndrome that can be a manifestation of variety of disorders. WG, a multisystem necrotising granulomatous vasculitis should always be considered as a possible etiological factor in these patients with or without involvement of other systems, as an early diagnosis and aggressive management with cytotoxic drugs offer best chances of survival in these patients. We report a rare case of 45-year-old woman who presented with massive hemoptysis in accident and emergency department and subsequently diagnosed as WG, and discuss the differential diagnosis and review the literature of this rare complication of WG. Approximately 41 cases have been reported so far of this rare complication.

Entities:  

Keywords:  Diffuse alveolar haemorrhage (DAH); Wegener’s granulomatosis (WG); antineutrophil cytoplasmic antibodies (ANCA); computed tomography (CT)

Year:  2014        PMID: 25525588      PMCID: PMC4256243          DOI: 10.3978/j.issn.2223-4292.2014.07.03

Source DB:  PubMed          Journal:  Quant Imaging Med Surg        ISSN: 2223-4306


  5 in total

Review 1.  Small vessel vasculitis of the lung.

Authors:  M I Schwarz; K K Brown
Journal:  Thorax       Date:  2000-06       Impact factor: 9.139

Review 2.  Pulmonary manifestations of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis.

Authors:  D R Thickett; A G Richter; N Nathani; G D Perkins; L Harper
Journal:  Rheumatology (Oxford)       Date:  2006-01-17       Impact factor: 7.580

3.  Antineutrophil cytoplasmic antibody-associated vasculitis complicated with diffuse alveolar hemorrhage: a study of 12 cases.

Authors:  Yi Lin; Wenjie Zheng; Xinping Tian; Xuan Zhang; Fengchun Zhang; Yi Dong
Journal:  J Clin Rheumatol       Date:  2009-10       Impact factor: 3.517

Review 4.  Diffuse alveolar hemorrhage: diagnosing it and finding the cause.

Authors:  Octavian C Ioachimescu; James K Stoller
Journal:  Cleve Clin J Med       Date:  2008-04       Impact factor: 2.321

5.  Wegener's granulomatosis in a middle-aged woman presenting with dyspnea, rash, hemoptysis and recurrent eye complaints: a case report.

Authors:  Jose Cardenas-Garcia; Dimitrios Farmakiotis; Berta-Paola Baldovino; Peter Kim
Journal:  J Med Case Rep       Date:  2012-10-03
  5 in total
  2 in total

Review 1.  Methylprednisolone and plasmapheresis are effective for life-threatening diffuse alveolar hemorrhage and gastrointestinal hemorrhage in granulomatosis with polyangiitis: A case report and literature review.

Authors:  Shen Ning; Xinhua Zhang; Cheng Xu; Xin Dang; Hao Cheng; Kejian Zhu; Yongmei Han
Journal:  Medicine (Baltimore)       Date:  2018-04       Impact factor: 1.889

2.  Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report.

Authors:  Xiao-Jie Li; Liu Yang; Xiao-Feng Yan; Chu-Ting Zhan; Jiang-Hua Liu
Journal:  World J Clin Cases       Date:  2021-04-06       Impact factor: 1.337

  2 in total

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