Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan.

BACKGROUND AND
OBJECTIVE: The prevalence and mortality of chronic obstructive pulmonary disease (COPD) in elderly patients are increasing worldwide. Low body mass index (BMI) is a well-known prognostic factor for COPD. However, the obesity paradox in elderly patients with COPD has not been well elucidated. We investigated the association between BMI and in-hospital mortality in elderly COPD patients.
METHODS: Using the Diagnosis Procedure Combination database in Japan, we retrospectively collected data for elderly patients (>65 years) with COPD who were hospitalized between July 2010 and March 2013. We performed multivariable logistic regression analysis to compare all-cause in-hospital mortality between patients with BMI of <18.5 kg/m2 (underweight), 18.5-22.9 kg/m2 (low-normal weight), 23.0-24.9 kg/m2 (high-normal weight), 25.0-29.9 kg/m2 (overweight), and ≥30.0 kg/m2 (obesity) with adjustment for patient backgrounds.
RESULTS: In all, 263,940 eligible patients were identified. In-hospital mortality was 14.3%, 7.3%, 4.9%, 4.3%, and 4.4%, respectively, in underweight, low-normal weight, high-normal weight, overweight, and obese patients. Underweight patients had a significantly higher mortality than low-normal weight patients (odds ratio [OR]: 1.55, 95% confidence interval [CI]: 1.48-1.63), whereas lower mortality was associated with high-normal weight (OR: 0.76, CI: 0.70-0.82), overweight (OR: 0.73, CI: 0.66-0.80), and obesity (OR: 0.67, CI: 0.52-0.86). Higher mortality was significantly associated with older age, male sex, more severe dyspnea, lower level of consciousness, and lower activities of daily living.
CONCLUSION: Overweight and obese patients had a lower mortality than low-normal weight patients, which supports the obesity paradox.

Introduction

Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease that interferes with normal breathing and is not fully reversible. Worldwide, an estimated 64 million people had moderate-to-severe COPD in 2004, and it caused the deaths of over 3 million individuals in 2005.1 Prevalence and mortality in COPD are higher in older patients,2 and there is an independent association between older patients with COPD and higher mortality.3,4

Low body mass index (BMI) is a potential prognostic factor for short- and long-term mortality in COPD.5–9 However, the relationship between obesity and mortality of COPD is controversial. The obesity paradox, which is based on a protective effect of adipose tissue against mortality, has been observed in various chronic diseases, including cardiovascular disease,10 chronic heart failure,11 stroke,12 chronic kidney disease,13 type 2 diabetes mellitus,14 and pulmonary hypertension.15 Further, the obesity paradox has been reported in respiratory diseases,16 and the possibility of an obesity paradox in COPD has been discussed.17,18 However, the obesity paradox in patients with COPD has not been adequately examined. Further, most studies demonstrating the association between low BMI and higher mortality in chronic diseases have been conducted in Western populations. It has been found that Asian populations have a different association between BMI and health risks to Western populations; this is because Asians have a lower mean BMI than non-Asians and Asians have a higher percentage of body fat than non-Asians with a similar BMI.19

Using a nationwide inpatient database, we aimed to evaluate the association between BMI and mortality in elderly patients with COPD in Japan.

Methods

Data source

The Diagnosis Procedure Combination database is a nationwide inpatient database in Japan. The database includes administrative claims data and discharge abstract data. Main diagnosis, comorbidities present on admission, and complications occurring during hospitalization are coded using the International Classification of Disease and Related Health Problems, 10th Revision (ICD-10) codes accompanied by text data in Japanese. The database also contains the following details: type of admission (emergent or non-emergent), patient’s age, sex, body height and weight, smoking index (defined as the number of cigarettes smoked per day multiplied by the number of years smoked), severity of dyspnea based on the Hugh-Jones dyspnea scale,20 levels of consciousness based on the Japan Coma Scale,21,22 on admission, activities of daily life on admission converted to the Barthel index,23 intensive care unit admission during hospitalization, use of mechanical ventilation, and discharge status. The grading of dyspnea severity was based on the Hugh-Jones classification20 and defined as follows: 1) the patient’s breathing was as good as that of other people of their age and build when working, walking, and climbing hills or stairs; 2) the patient could walk at the same pace as healthy people of their age and build on level ground but was unable to maintain that pace on hills or stairs; 3) the patient was unable to maintain the pace of healthy people of their age and build on level ground but could walk about 1.6 kilometers or more at their own speed; 4) the patient was unable to walk more than about 50 meters on level ground without a rest; 5) the patient was breathless when talking or undressing or was unable to leave their home because of breathlessness; and (unspecified) the patient could not be classified into the above grades because of their bedridden status. The numbers of participating hospitals were 980, 1,075, and 1,057, respectively, for July 2010 to March 2011, April 2011 to March 2012, and April 2012 to March 2013.

This study was approved by the Institutional Review Board of The University of Tokyo. It waived the requirement for patient informed consent because of the anonymous nature of the data.

Patient selection

We retrospectively collected data for patients aged over 65 years who had been admitted to hospital because of COPD (ICD-10 codes J41, J42, J43, J44) as the main diagnosis, or who had been admitted for any cause but had COPD as comorbidity on admission, and were discharged between July 1, 2010 and March 31, 2013. COPD and other comorbidities were based on physician diagnosis.

Comorbidities on admission

The following comorbidities were identified using ICD-10 codes: pneumonia caused by pathogenic microbes (J10–J18); asthma (J45, J46); aspiration pneumonia (J69); interstitial pneumonia (J84); pulmonary embolism (I26); respiratory failure (J96); lung cancer (C34); heart failure (I50); ischemic heart disease (IHD; I20–I22, I25); cardiac arrhythmia (I44, I45, I47–I49); cerebral vascular diseases (I60–I69); chronic liver disease (K70, K71, K73, K74, K76); chronic renal failure (N18); anxiety (F40–F41); depression (F30–F33); and bone fracture (S02, S12, S22, S32, S42, S52, S62, S72, S82, S92, T02, T10, T12).

BMI categories

BMI categories were assigned based on World Health Organization classifications of underweight (BMI <18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25.0–29.9 kg/m2), and obese (≥30.0 kg/m2) individuals. Normal weight was further divided into low–normal (18.5–22.9 kg/m2) and high– normal (23.0–24.9 kg/m2).24,25

Outcome

The primary outcome was all-cause in-hospital mortality.

Statistical analysis

We used chi-square tests to examine differences in categorical variables. We performed a multivariable logistic regression for in-hospital mortality to analyze patient-level factors associated with the outcome after adjustment for within-hospital clustering by means of a generalized estimating equation.26 For the BMI categories, we defined the low–normal weight group as the reference category. The threshold for significance was P<0.05. We performed all statistical analyses using SPSS software (v20; IBM, Armonk, NY, USA).

Results

Among 19 million patients during the 33 months between July 2010 and March 2013, we found 263,940 patients with COPD who were aged over 65 years. The mean age was 77.8 years (standard deviation [SD]: 7.2), and the proportions of males and females were 80.0% (n=211,057) and 20.0% (n=52,883), respectively. The mean number of smoking pack-years was 55.6 (SD: 35.6). Detailed clinical characteristics and primary diagnoses on admission appear in Table S1. Table 1 shows the patient characteristics divided by BMI category. We observed that the mean age increased with decreasing BMI. The proportion of patients aged over 85 years was higher in the underweight group, but lower in the overweight and obese groups. The percentage of males was higher in the underweight group. The proportion of patients with severe dyspnea (Hugh-Jones class V) was lowest (14.6%) in the overweight group and highest (27.1%) in the underweight group. Disability scores, consciousness levels, and types of admission showed similar patterns to the dyspnea grades.

Table 1

Characteristics and comorbidities in elderly patients with COPD

	Body mass index category (kg/m2)					P-value
	Underweight (<18.5) (n=82,467)	Low–normal weight (18.5–22.9) (n=113,837)	High–normal weight (23.0–24.9) (n=35,152)	Overweight (25.0–29.9) (n=28,594)	Obesity (≥30) (n=3,890)
	n (%)	n (%)	n (%)	n (%)	n (%)
Age (years), mean [SD]	79.1 [7.3]	77.8 [7.2]	76.6 [6.8]	76.1 [6.6]	75.8 [6.5]	<0.001
65–74 years	23,226 (28.2)	39,269 (34.5)	14,045 (40.0)	12,252 (42.8)	1,689 (43.4)
75–84 years	39,210 (47.5)	53,822 (47.3)	16,526 (47.0)	13,144 (46.0)	1,814 (46.6)
85+ years	20,031 (24.3)	20,746 (18.2)	4,581 (13.0)	3,198 (11.2)	387 (9.9)
Sex						<0.001
Male	64,352 (78.0)	93,244 (81.9)	28,964 (82.4)	22,193 (77.6)	2,304 (59.2)
Female	18,115 (22.0)	20,593 (18.1)	6,188 (17.6)	6,401 (22.4)	1,586 (40.8)
Dyspnea grade						<0.001
I	5,631 (10.2)	13,210 (19.3)	5,090 (24.9)	4,108 (26.1)	424 (21.3)
II	6,586 (11.9)	11,480 (16.7)	3,730 (18.2)	2,889 (18.4)	330 (16.5)
III	6,751 (12.2)	9,757 (14.2)	2,982 (14.6)	2,281 (14.5)	257 (12.9)
IV	12,782 (23.0)	14,370 (21.0)	3,914 (19.1)	2,882 (18.3)	402 (20.2)
V	15,047 (27.1)	12,872 (18.8)	3,074 (15.0)	2,286 (14.6)	402 (20.2)
Unspecified	8,666 (15.6)	6,858 (10.0)	1,652 (8.1)	1,265 (8.1)	180 (9.0)
Disability of ADL						<0.001
20	26,820 (38.1)	57,248 (56.9)	20,668 (65.4)	17,143 (66.5)	1,976 (58.0)
15–19	7,860 (11.2)	10,601 (10.5)	3,007 (9.5)	2,458 (9.5)	416 (12.2)
14–10	9,849 (14.0)	10,808 (10.7)	2,867 (9.1)	2,204 (8.6)	360 (10.6)
9–5	6,646 (9.4)	6,472 (6.4)	1,612 (5.1)	1,313 (5.1)	202 (5.9)
0–4	19,237 (27.3)	15,477 (15.4)	3,441 (10.9)	2,648 (10.3)	454 (13.3)
Level of consciousness						<0.001
Alert	69,718 (86.1)	102,942 (91.3)	32,693 (93.7)	26,734 (94.0)	3,587 (92.7)
Dull	7,950 (9.8)	7,250 (6.4)	1,649 (4.7)	1,274 (4.5)	206 (5.3)
Somnolence	1,989 (2.5)	1,426 (1.3)	304 (0.9)	234 (0.8)	48 (1.2)
Coma	1,330 (1.6)	1,077 (1.0)	255 (0.7)	191 (0.7)	27 (0.7)
Type of hospital admission						<0.001
Scheduled	32,521 (39.4)	59,478 (52.2)	20,940 (59.6)	17,542 (61.3)	2,226 (57.2)
Emergency	49,946 (60.6)	54,359 (47.8)	14,212 (40.4)	11,052 (38.7)	1,664 (42.8)
Comorbidities
Asthma	10,827 (13.1)	16,294 (14.3)	5,263 (15.0)	4,341 (15.2)	771 (19.8)	<0.001
Pneumonia	22,637 (27.4)	23,753 (20.9)	6,089 (17.3)	4,262 (14.9)	517 (13.3)	<0.001
Aspiration pneumonia	7,755 (9.4)	4,884 (4.3)	924 (2.6)	569 (2.0)	69 (1.8)	<0.001
Interstitial pneumonitis	3,285 (4.0)	6,419 (5.6)	2,509 (7.1)	1,981 (6.9)	206 (5.3)	<0.001
Respiratory failure	23,995 (29.1)	22,822 (20.0)	5,692 (16.2)	4,314 (15.1)	702 (18.0)	<0.001
Lung cancer	12,231 (14.8)	25,733 (22.6)	9,128 (26.0)	7,098 (24.8)	621 (16.0)	<0.001
Heart failure	13,935 (16.9)	17,327 (15.2)	4,881(13.9)	4,261 (14.9)	821 (21.1)	0.001
Ischemic heart disease	6,766 (8.2)	12,524 (11.0)	4,656 (13.2)	4,339 (15.2)	559 (14.4)	<0.001
Pulmonary embolism	250 (0.3)	406 (0.4)	147 (0.4)	154 (0.5)	46 (1.2)	0.049
Cardiac arrhythmia	5,120 (6.2)	8,122 (7.1)	2,567 (7.3)	2,240 (7.8)	323 (8.3)	0.144
Cerebrovascular disease	6,452 (7.8)	8,933 (7.8)	2,609 (7.4)	2,148 (7.5)	275 (7.1)	0.448
Liver disease	1,279 (1.6)	2,055 (1.8)	703 (2.0)	621 (2.2)	107 (2.8)	<0.001
Chronic renal failure	1,986 (2.4)	3,382 (3.0)	938 (2.7)	779 (2.7)	148 (3.8)	<0.001
Anxiety/depression	1,378 (1.7)	1,762 (1.5)	542 (1.5)	455 (1.6)	79 (2.0)	0.041
Bone fracture	3,473 (4.2)	3,605 (3.2)	865 (2.5)	642 (2.2)	87 (2.2)	0.011

Note: Data were expressed as number (%) or mean[SD].

Abbreviations: ADL, activities of daily life; COPD, chronic obstructive pulmonary disease; SD, standard deviation.

The percentage of the following comorbidities was higher in the lower BMI categories: pneumonia caused by pathogenic microbes, aspiration pneumonia, respiratory failure, heart failure, and bone fracture. In contrast, the percentage of the following comorbidities was higher in the higher BMI categories: asthma, interstitial pneumonitis, IHD, liver disease, and chronic renal failure. Figure 1 shows all-cause in-hospital mortality for each BMI category. In-hospital mortality was 14.3%, 7.3%, 4.9%, 4.3%, and 4.4%, respectively, in the underweight, low–normal weight, high–normal weight, overweight, and obese groups.

Figure 1

All-cause in-hospital mortality among elderly patients with COPD according to body mass index category.

Abbreviation: COPD, chronic obstructive pulmonary disease.

Table 2 shows the results of the logistic regression analysis for all-cause in-hospital mortality. The underweight group had a significantly higher mortality than the reference low–normal weight group. The overweight and obese groups had significantly lower mortality rates than the reference group. Older age, male sex, more severe dyspnea scores, lower activities of daily life scores, and lower levels of consciousness were also significantly associated with higher mortality. Emergency admission in elderly COPD patients was likewise associated with high mortality. Regarding pulmonary comorbidities, higher mortality was significantly associated with pneumonia caused by pathogenic microbes, aspiration pneumonia, interstitial pneumonitis, respiratory failure, and lung cancer. With extrapulmonary comorbidities, higher mortality was associated with heart failure, liver disease, chronic renal failure, and bone fracture. Conversely, lower mortality was associated with asthma, IHD, and cerebrovascular diseases. Emergency admission in elderly COPD patients was also associated with high mortality.

Table 2

Multivariable logistic regression analysis for all-cause in-hospital mortality

	Adjusted odds ratio	95% confidence interval	P-value
Body mass index (kg/m2)
<18.5	1.55	1.48–1.63	<0.001
18.5–22.9	Reference
23–24.9	0.76	0.70–0.82	<0.001
25–29.9	0.73	0.66–0.80	<0.001
≥30	0.67	0.52–0.86	<0.002
Age
65–74 years	Reference
75–84 years	1.17	1.11–1.24	<0.001
85+ years	1.33	1.24–1.41	<0.001
Sex
Male	Reference
Female	0.61	0.57–0.65	<0.001
Dyspnea grade
I	Reference
II	1.72	1.48–2.01	<0.001
III	2.58	2.19–3.03	<0.001
IV	3.96	3.36–4.68	<0.001
V	10.78	9.03–12.86	<0.001
Unspecified	10.06	8.33–12.15	<0.001
Disability of ADL
20	Reference
19–15	1.49	1.35–1.64	<0.001
14–10	2.00	1.83–2.18	<0.001
9–5	2.71	2.45–3.00	<0.001
4–0	4.32	3.91–4.76	<0.001
Consciousness level
Alert	Reference
Dull	1.21	1.12–1.30	<0.001
Somnolence	1.53	1.37–1.71	<0.001
Coma	2.87	2.53–3.26	<0.001
Emergency admission	1.43	1.33–1.54	<0.001
Asthma	0.57	0.53–0.61	<0.001
Pneumonia	1.08	1.02–1.14	0.005
Aspiration pneumonia	1.18	1.09–1.28	<0.001
Interstitial pneumonitis	2.28	2.12–2.45	<0.001
Respiratory failure	1.15	1.09–1.22	<0.001
Lung cancer	3.89	3.63–4.17	<0.001
Heart failure	1.21	1.14–1.28	<0.001
Ischemic heart disease	0.87	0.80–0.95	<0.001
Pulmonary embolism	1.25	0.89–1.74	0.192
Cardiac arrhythmia	1.07	0.99–1.17	0.106
Cerebrovascular disease	0.83	0.76–0.91	<0.001
Liver disease	1.30	1.08–1.56	0.005
Chronic renal failure	1.64	1.44–1.87	<0.001
Anxiety/depression	1.033	0.87–1.23	0.721
Bone fracture	1.41	1.20–1.65	<0.001

Abbreviation: ADL, activities of daily life.

Discussion

This study used a national inpatient database in Japan to investigate the association between BMI and mortality in 263,940 elderly inpatients with COPD. Underweight patients had a significantly higher mortality than low–normal weight patients, whereas overweight and obese patients showed significantly lower mortality rates. The present study is the first to demonstrate the obesity paradox in all-cause in-hospital mortality in elderly patients with COPD in a nationwide setting.

Previous studies on BMI and COPD mortality have found low BMI to be associated with high mortality in COPD patients.5–9 One limited investigation determined that higher mortality was associated with lower BMI and that mortality decreased with increasing BMI in severe COPD; however, in mild and moderate COPD, the lowest mortality was found in patients with normal BMI.7 Most studies evaluating BMI and mortality in COPD have not examined the association between being overweight or obese and lower mortality in COPD patients. In the present study, higher mortality was associated with underweight, which concurs with the results of previous studies,5–9 which found lower BMI to be associated with higher mortality in COPD. Moreover, we found that lower mortality was associated with overweight and obesity, which supports the obesity paradox in elderly patients with COPD.

Generally, overweight and obesity are well-known risk factors for several chronic diseases and all-cause mortality in healthy individuals. However, one systematic review of cohort studies examined the association between BMI and total mortality in patients with coronary artery disease; it found that compared with normal BMI patients, those with low BMI (<20 kg/m2) had an increased risk for all-cause mortality and that overweight patients (BMI 25–29.9 kg/m2) had the lowest mortality risk. Obese patients (BMI ≥30 kg/m2) showed no increased risk for total mortality.10 These findings appear to be at variance with the above-mentioned prevailing orthodoxy. Similarly, this paradoxical association between obesity and mortality has been reported for chronic heart failure,11 stroke,12 chronic kidney disease,13 type 2 diabetes mellitus,14 and pulmonary hypertension.15 This phenomenon is referred to as the obesity paradox. However, this paradoxical association between mortality and BMI has not been previously evaluated in COPD patients.

Even though overweight and obesity have not been well-elucidated in COPD patients, there is evidence in the literature that overweight and obesity may be related to poor outcomes with COPD. Overweight and obesity have been reported to be associated with reduced forced expiratory volume in 1 second (FEV1), and weight gain has been shown to reduce pulmonary function longitudinally.27,28 COPD patients are at increased risk of developing obesity since they have decreased physical activity owing to exertional dyspnea and long-term use of systemic glucocorticosteroids to prevent exacerbation;17 this suggests a potential link between obesity and COPD. Epidemiologically, obesity has been found to be more prevalent in COPD patients than in the general population, and the prevalence of obesity was more frequent in early-stage COPD.17 Thus, the harmful long-term effects related to obesity may result in poor outcomes with COPD. In addition, it has been suggested that obesity is related to systemic inflammation in COPD by releasing pro-inflammatory cytokines from adipose tissue and that it contributes to the development of comorbidities and exacerbations in COPD.17,29 Further, insulin resistance, which is a common underlying pathophysiological finding in metabolic syndrome, is reportedly increased in COPD, and it may contribute to systemic extrapulmonary complications, which are linked to systemic low-grade inflammation in COPD patients.30 Therefore, obesity and overweight have been recognized as being associated with the severity of COPD, and obesity and overweight may exert undesirable effects in COPD patients. However, the present study demonstrated that overweight and obese patients had lower mortality rates than those with low–normal weight, which supports the existence of an obesity paradox in elderly patients with COPD.

Some studies have reported a favorable effect of obesity in COPD.31–33 It is reasonable to predict that obese COPD patients are more likely to experience greater dyspnea and exercise intolerance and may have poor prognosis; however, recent evidence suggests that obese COPD patients have similar or better dyspnea scores during exercise and do not have diminished exercise capacity compared with normal-weight COPD patients.32,33 In pulmonary function tests, obese COPD patients had both a reduced end-expiratory lung volume and a preserved inspiratory capacity;31 these are related to dyspnea scores and are favorable prognostic implications for patients with COPD.34 In addition, the annual decline in FEV1 in obese men with COPD was lower than in males with normal BMI; however, this effect was not observed in women, which indicates that obesity and overweight may exert protective effects in the progressive airflow limitation in COPD.35 The precise physiological mechanism of the obesity paradox in COPD remains unknown, though.

IHD is well-known to be a major comorbidity in COPD owing to shared risk factors of smoking and systemic low-grade inflammation.36,37 The prevalence of IHD in COPD patients has been reported to vary between 4.7% and 60%.38,39 In a population-based study, coronary artery disease was found in 7%–13% of patients diagnosed with COPD.40,41 The prevalence of IHD in the present study was 10.9% in elderly COPD patients, and this figure is comparable with that reported in previous studies.40,41 Further, since both IHD and COPD are leading causes of death, the coexistence of IHD and COPD worsens the prognosis for both diseases. It has been reported that COPD is a predictor of cardiovascular disease mortality; in particular, the association between COPD and cardiovascular disease was stronger in adults aged under 65 years.42 This suggests that cardiovascular disease should be evaluated and treated with particular care in younger adults with COPD.

Asthma often coexists with COPD,43 and asthma–COPD overlap syndrome has been investigated.44 Hardin et al demonstrated that patients with that syndrome frequently underwent COPD exacerbation, showed worse health-related quality of life,45 and could have a poorer prognosis than COPD patients without asthma. However, Fu et al found that COPD patients had a poorer prognosis than patients with asthma–COPD overlap syndrome: the former showed decreased lung function and reduced performance in the 6-minute walk test.46 Fu et al discussed the possibility that the overlap syndrome had a protective effect on disease activity; they suggested that less airway reversibility at baseline is associated with the development of irreversible airflow obstruction, which contributes to a poor prognosis.46,47 The present study also demonstrated that elderly COPD patients with asthma had a better prognosis than those with COPD alone; this confirms the better prognosis in elderly patients with asthma–COPD overlap syndrome. The use of inhaled glucocorticosteroids is effective for treating obstructive inflammatory airway diseases and reduced COPD exacerbation; it is recommended that patients with asthma–COPD overlap syndrome be treated with inhaled corticosteroids,44 and thus may have a better prognosis than patients with COPD alone.

Several limitations in the present study should be acknowledged. Since we based the diagnosis of COPD on physician-diagnosed COPD, the accuracy of COPD diagnosis was not confirmed by specialists. However, in actual practice, COPD is not always diagnosed by specialists; thus, data relating to physician-diagnosed COPD, such as those in epidemiological studies and the present study, are a valuable source of information. In addition, since the Diagnosis Procedure Combination database does not include the stages of COPD severity or details of pulmonary function tests, including FEV1 and other indices, the severity of COPD could not be precisely evaluated in this study.

In conclusion, this study demonstrates that higher mortality was associated with underweight; lower mortality was associated with overweight and obesity in elderly COPD patients. This supports the existence of the obesity paradox in elderly patients with COPD.

Table S1

Patient’s clinical characteristics

	Mean	SD	Patients number (n) (total n=263,940)	Prevalence (%)
Age (years)	77.8	7.2
Sex
Male			211,057	80.0
Female			52,883	20.0
BMI (kg/m2)	20.6	3.9
Smoking
Pack-year	55.6	35.6
Dyspnea grade by Hugh-Jones classification†
I			28,463	17.6
II			25,015	15.4
III			22,028	13.6
IV			34,350	21.2
V			33,681	20.8
Unspecified			18,621	11.5
Level of consciousness by Japan coma scale†
Alert			235,674	90.3
Dull			18,329	7.0
Somnolence			4,001	1.5
Coma			2,880	1.1
Disability of ADL by Barthel Index†
20			123,855	53.4
15–19			24,342	10.5
10–14			26,088	11.3
5–9			16,245	7.0
0			41,257	17.8
Style of hospital admission
Scheduled			132,707	50.3
Emergency			131,233	49.7
Primary diagnosis at admission
Respiratory disease			107,778	40.8
COPD			23,447	8.9
Acute exacerbation			4,207	1.6
Viral infection			765	0.3
Asthma			5,067	1.9
Pneumonia			37,283	14.1
Aspiration pneumonia			9,521	3.6
Interstitial pneumonia			4,590	1.7
Respiratory failure			13,302	5
Others			9,596	3.7
Lung cancer			40,566	15.4
Cardiac disease			20,295	7.7
Heart failure			9,986	3.8
Ischemic heart disease			5,862	2.2
Pulmonary embolism			295	0.1
Cardiac arrhythmia			1,149	0.4
Others			3,003	1.2
Cerebrovascular disease			1,603	0.6
Liver disease			628	0.2
Chronic renal failure			985	0.4
Bone fracture			6,502	2.5
Others			85,583	32.4
During hospitalization
ICU admission			14,683	6.2
Mechanical ventilation			20,615	7.8
Death‡			7,188	34.9

Notes: Prevalence was expressed by percentage of total patients, unless otherwise indicated.

Prevalence was expressed as percentage of each factor among number of patients in each factor.

Prevalence was expressed as percentage of deaths among the number of patients who underwent mechanical ventilation.

Abbreviations: ADL, activities of daily life; BMI, body mass index; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; SD, standard deviation.