OBJECTIVE: Osteogenesis imperfecta (OI) is a rare disease leading to recurrent fractures, hyperlaxicity of ligaments, short stature and muscular weakness. Physiotherapy is one important treatment approach. The objective of our analysis was to evaluate the effect of a new physiotherapy approach including side alternating whole body vibration on motor function in children with OI. METHODS: In a retrospective analysis data of 53 children were analyzed. The 12 months approach included 6 months of side alternating whole body vibration training, concomitant physiotherapy, resistance training, treadmill training and 6 months follow up. Primary outcome parameter was the Gross Motor Function Measure after 12 months (M12). RESULTS: 53 children (male: 32; age (mean±SEM): 9.1±0.61, range 2.54-24.81 years) participated in the treatment approach. A significant increase of motor function (GMFM-66 score 55.47±2.45 to 58.67±2.83; p=0.001) and walking distance (47.04 m±6.52 to 63.36±8.25 m (p<0.01) between M0 and M12 was seen. Total body without head bone mineral density increased significantly at M12 (p=0.0189). CONCLUSIONS: In the cohort of OI children which participated in the specialized treatment approach improvements of motor function were observed. Therefore this program should be considered as additional therapeutic approach for children with severe OI.
OBJECTIVE:Osteogenesis imperfecta (OI) is a rare disease leading to recurrent fractures, hyperlaxicity of ligaments, short stature and muscular weakness. Physiotherapy is one important treatment approach. The objective of our analysis was to evaluate the effect of a new physiotherapy approach including side alternating whole body vibration on motor function in children with OI. METHODS: In a retrospective analysis data of 53 children were analyzed. The 12 months approach included 6 months of side alternating whole body vibration training, concomitant physiotherapy, resistance training, treadmill training and 6 months follow up. Primary outcome parameter was the Gross Motor Function Measure after 12 months (M12). RESULTS: 53 children (male: 32; age (mean±SEM): 9.1±0.61, range 2.54-24.81 years) participated in the treatment approach. A significant increase of motor function (GMFM-66 score 55.47±2.45 to 58.67±2.83; p=0.001) and walking distance (47.04 m±6.52 to 63.36±8.25 m (p<0.01) between M0 and M12 was seen. Total body without head bone mineral density increased significantly at M12 (p=0.0189). CONCLUSIONS: In the cohort of OI children which participated in the specialized treatment approach improvements of motor function were observed. Therefore this program should be considered as additional therapeutic approach for children with severe OI.
Authors: Victoria L Gremminger; Youngjae Jeong; Rory P Cunningham; Grace M Meers; R Scott Rector; Charlotte L Phillips Journal: J Bone Miner Res Date: 2019-06-13 Impact factor: 6.741
Authors: C Stark; P Herkenrath; H Hollmann; S Waltz; I Becker; L Hoebing; O Semler; H Hoyer-Kuhn; I Duran; B Hero; M Hadders-Algra; E Schoenau Journal: J Musculoskelet Neuronal Interact Date: 2016-09-07 Impact factor: 2.041
Authors: Danubia C Sá-Caputo; Carla da F Dionello; Éric Heleno F F Frederico; Laisa L Paineiras-Domingos; Cintia Renata Sousa-Gonçalves; Danielle S Morel; Eloá Moreira-Marconi; Marianne Unger; Mario Bernardo-Filho Journal: Afr J Tradit Complement Altern Med Date: 2017-03-01
Authors: S Langensiepen; C Stark; R Sobottke; O Semler; J Franklin; M Schraeder; J Siewe; P Eysel; E Schoenau Journal: J Musculoskelet Neuronal Interact Date: 2017-12-01 Impact factor: 2.041