| Literature DB >> 25524954 |
Alfredo Ramirez1, Steffen Wolfsgruber2, Carolin Lange3, Hanna Kaduszkiewicz3, Siegfried Weyerer4, Jochen Werle4, Michael Pentzek5, Angela Fuchs5, Steffi G Riedel-Heller6, Tobias Luck7, Edelgard Mösch8, Horst Bickel8, Birgitt Wiese9, Jana Prokein9, Hans-Helmut König10, Christian Brettschneider10, Monique M Breteler11, Wolfgang Maier2, Frank Jessen2, Martin Scherer3.
Abstract
Type 2 diabetes mellitus (T2DM) is a risk factor of dementia. The effect of T2DM treatment quality on dementia risk, however, is unclear. 1,342 elderly individuals recruited via general practitioner registries (AgeCoDe cohort) were analyzed. This study analyzed the association between HbA1c level and the incidence of all-cause dementia (ACD) and of Alzheimer's disease dementia (referred to here as AD). HbA1c levels ≥6.5% were associated with 2.8-fold increased risk of incident ACD (p = 0.027) and for AD (p = 0.047). HbA1c levels ≥7% were associated with a five-fold increased risk of incident ACD (p = 0.001) and 4.7-fold increased risk of incident AD (p = 0.004). The T2DM diagnosis per se did not increase the risk of either ACD or AD. Higher levels of HbA1c are associated with increased risk of ACD and AD in an elderly population. T2DM diagnosis was not associated with increased risk if HbA1c levels were below 7%.Entities:
Keywords: Alzheimer's disease; diabetes mellitus; epidemiology; glycosylated hemoglobin; incident dementia
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Year: 2015 PMID： 25524954 DOI： 10.3233/JAD-141521
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472