Daniela A Rubin1, Susan J Clark2, Jason Ng3, Diobel M Castner4, Andrea M Haqq5, Daniel A Judelson4. 1. Department of Kinesiology, California State University, Fullerton, 800N. State College Blvd, CA, 92834 USA. Electronic address: drubin@fullerton.edu. 2. Department of Endocrinology, Children's Hospital of Orange County, 1201W La Veta, Orange, CA, 92868 USA. 3. Department of Kinesiology, California State University, Fullerton, 800N. State College Blvd, CA, 92834 USA; Department of Kinesiology, The University of Alabama, Tuscaloosa, AL, 35487, USA. 4. Department of Kinesiology, California State University, Fullerton, 800N. State College Blvd, CA, 92834 USA. 5. Department of Pediatrics, University of Alberta, 11405-87 Avenue, Edmonton, AB, T6G 2R3, Canada.
Abstract
OBJECTIVE: Excess adiposity affects endocrine and metabolic function at rest and during exercise. This study evaluated the endocrine and metabolic responses to exercise in syndromic (Prader-Willi syndrome) and non-syndromic pediatric obesity. MATERIALS/ METHODS: Eleven PWS (10.9±1.6 y, 45.4±9.5% body fat), 12 lean (9.4±1.2 y, 17.5±4.6% body fat), and 12 obese (9.2±1.2 y, 39.9±6.8% body fat) children completed ten two-minute cycling exercise bouts, separated by one-minute rest. Blood samples were obtained at rest pre-exercise (PRE), immediately post-exercise (IP), and 15, 30 and 60 minutes into recovery. Samples were analyzed for hormones and metabolites. RESULTS: Growth hormone increased in response to exercise in lean and obese but not PWS (IP>PRE; IP: lean>obese). Epinephrine increased with exercise in lean (IP>PRE), while norepinephrine increased in lean and obese (IP>PRE) but not PWS; no differences were observed between lean and obese groups at IP. No other significant hormonal group interactions existed. Glucose, lactate, free fatty acid, glycerol and ketone responses were similar among groups. CONCLUSION: PWS children exhibited altered stress hormone responses to exercise. However, glucose-regulating hormones and metabolic responses to exercise appeared normal.
OBJECTIVE: Excess adiposity affects endocrine and metabolic function at rest and during exercise. This study evaluated the endocrine and metabolic responses to exercise in syndromic (Prader-Willi syndrome) and non-syndromic pediatric obesity. MATERIALS/ METHODS: Eleven PWS (10.9±1.6 y, 45.4±9.5% body fat), 12 lean (9.4±1.2 y, 17.5±4.6% body fat), and 12 obese (9.2±1.2 y, 39.9±6.8% body fat) children completed ten two-minute cycling exercise bouts, separated by one-minute rest. Blood samples were obtained at rest pre-exercise (PRE), immediately post-exercise (IP), and 15, 30 and 60 minutes into recovery. Samples were analyzed for hormones and metabolites. RESULTS: Growth hormone increased in response to exercise in lean and obese but not PWS (IP>PRE; IP: lean>obese). Epinephrine increased with exercise in lean (IP>PRE), while norepinephrine increased in lean and obese (IP>PRE) but not PWS; no differences were observed between lean and obese groups at IP. No other significant hormonal group interactions existed. Glucose, lactate, free fatty acid, glycerol and ketone responses were similar among groups. CONCLUSION:PWSchildren exhibited altered stress hormone responses to exercise. However, glucose-regulating hormones and metabolic responses to exercise appeared normal.
Authors: Maha Alsaif; Sarah A Elliot; Michelle L MacKenzie; Carla M Prado; Catherine J Field; Andrea M Haqq Journal: Adv Nutr Date: 2017-11-15 Impact factor: 8.701
Authors: Krystal A Irizarry; Diana R Mager; Lucila Triador; Michael J Muehlbauer; Andrea M Haqq; Michael Freemark Journal: Clin Endocrinol (Oxf) Date: 2019-01-31 Impact factor: 3.478