Literature DB >> 2552373

Nerve growth factor-induced differentiation in PC-12 cells is blocked by fos oncogene.

E Ito1, J L Sonnenberg, R Narayanan.   

Abstract

Rat pheochromocytoma (PC-12) cells respond to nerve growth factor (NGF) by cessation of cell division and by expression of several properties resembling those of differentiated sympathetic neurons. Within minutes after addition, NGF rapidly stimulates transient expression of c-fos. To investigate the possible role of c-fos in NGF-induced differentiation, activated mouse c-fos genes were introduced into PC-12 cells by electroporation. Constitutive expression of fos inhibited NGF-induced differentiation although transfected cells harbored intact NGF receptors. Dibutyryl cyclic AMP (db cAMP) and basic fibroblast growth factor (b-FGF)-induced differentiation were also inhibited. Transcriptional activation of c-fos, c-jun, and ornithine decarboxylase (ODC) by NGF was down-regulated, whereas expression of egr-1 was unaffected in PC-12 fos clones. These results suggest that deregulated expression of fos can interfere with the normal role of NGF in neuronal differentiation.

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Year:  1989        PMID： 2552373

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  15 in total

Review 1.  Fos-jun and the primary genomic response in the nervous system. Possible physiological role and pathophysiological significance.

Authors:  J P Doucet; S P Squinto; N G Bazan
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

2.  Coordinated expression of intermediate biomarkers for tumorigenic transformation in RAS-transfected mouse mammary epithelial cells.

Authors:  N T Telang; R Narayanan; H L Bradlow; M P Osborne
Journal:  Breast Cancer Res Treat       Date:  1991-08       Impact factor: 4.872

3.  On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells.

Authors:  E Kontny; F Ciruela; P Svenningsson; C F Ibáñez; B B Fredholm
Journal:  J Mol Neurosci       Date:  1997-02       Impact factor: 3.444

4.  GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases.

Authors:  L E Heasley; B Storey; G R Fanger; L Butterfield; J Zamarripa; D Blumberg; R A Maue
Journal:  Mol Cell Biol       Date:  1996-02       Impact factor: 4.272

5.  The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

Authors:  K W Wood; H Qi; G D'Arcangelo; R C Armstrong; T M Roberts; S Halegoua
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

6.  Neoplastic transformation of mouse mammary epithelial cells by deregulated myc expression.

Authors:  N T Telang; M P Osborne; L A Sweterlitsch; R Narayanan
Journal:  Cell Regul       Date:  1990-10

7.  Evidence for differential functions of the p50 and p65 subunits of NF-kappa B with a cell adhesion model.

Authors:  R Narayanan; K A Higgins; J R Perez; T A Coleman; C A Rosen
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

8.  Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts.

Authors:  C Wrighton; M Busslinger
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

9.  Adenovirus E1A proteins stimulate inositol phospholipid metabolism in PC12 cells.

Authors:  K Shiroki; A Yamakawa; M Shibata; T Takenawa; S Sugano; A Nomoto
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

10.  Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-zeta isoform.

Authors:  E S Coleman; M W Wooten
Journal:  J Mol Neurosci       Date:  1994       Impact factor: 3.444
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