Literature DB >> 2552322

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.

D McVey1, L Brizuela, I Mohr, D R Marshak, Y Gluzman, D Beach.   

Abstract

Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.

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Year:  1989        PMID： 2552322     DOI： 10.1038/341503a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  93 in total

1.  Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated.

Authors:  Ronald J Kim; Stephanie Moine; Danielle K Reese; Peter A Bullock
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

2.  Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.

Authors:  D M Virshup; A A Russo; T J Kelly
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

Review 3.  Nuclear protein phosphorylation and growth control.

Authors:  D W Meek; A J Street
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

Review 4.  Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture.

Authors:  E Fanning
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

5.  Interactions required for binding of simian virus 40 T antigen to the viral origin and molecular modeling of initial assembly events.

Authors:  Danielle K Reese; Kodangattil R Sreekumar; Peter A Bullock
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

6.  The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.

Authors:  L Chen; W S Joo; P A Bullock; D T Simmons
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

7.  Phosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.

Authors:  Jing Li; Jason Diaz; Xin Wang; Sabrina H Tsang; Jianxin You
Journal:  J Biol Chem       Date:  2014-12-05       Impact factor: 5.157

8.  Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

Authors:  K H Scheidtmann; M C Mumby; K Rundell; G Walter
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

9.  Differential induction of structural changes in the simian virus 40 origin of replication by T antigen.

Authors:  J A Borowiec; F B Dean; J Hurwitz
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

10.  Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains.

Authors:  K H Scheidtmann; M Buck; J Schneider; D Kalderon; E Fanning; A E Smith
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103
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