Ana Carolina Veiga Rodarte-Almeida1, Simon Petersen-Jones2, Ingeborg M Langohr3, Laurence Occelli2, Peterson T Dornbusch1, Naoye Shiokawa4, Fabiano Montiani-Ferreira1. 1. Veterinary Medicine Department, Federal University of Paraná, Rua dos Funcionários, 1540, Juvevê, Curitiba, PR, 80035-050, Brazil. 2. Small Animal Clinical Sciences, Veterinary Medical Center, Michigan State University, 736 Wilson Road, D-208, East Lansing, MI, 48824, USA. 3. Department of Pathobiological Sciences, School of Veterinary Medicine, 1909 Skip Bertman Drive, Baton Rouge, LA, 70803, USA. 4. Retina e Vítreo Consultoria, Rua Mateus Leme, 2285, Curitiba, PR, 80530-010, Brazil.
Abstract
OBJECTIVE: The purpose of this study was to investigate the inheritance and phenotype of retinal dysplasia (RD) in the American pit bull terrier. ANIMALS STUDIED: A breeding colony established from a single female pure-bred American pit bull terrier dog with RD. PROCEDURES: A female pure-bred American pit bull terrier with RD was donated to the Veterinary Hospital of Federal University of Paraná, Curitiba, Brazil. A breeding colony was established and the phenotype and inheritance of the condition investigated. Regular ophthalmic examinations and fundus photography were performed on three generations of offspring from the founder animal. Some animals were additionally studied by optical coherence tomography. Ocular histopathology was performed on some animals from the colony. RESULTS: Fifty-seven offspring were produced in two generations from the affected founder female. Thirty-two were diagnosed with RD and showed a spectrum of severity of lesions including multifocal, and or geographic lesions and some developed retinal detachment. Histologic examination demonstrated retinal folds, rosettes, and areas of retinal detachment. The affected dogs were shorter in stature than the unaffected littermates. Breeding studies suggested the trait has an autosomal dominant mode of inheritance. DNA testing showed that the affected dogs were negative for the known gene mutations for canine dwarfism with RD. CONCLUSION: This is a report of a novel inherited form of RD that affects American pit bull terriers.
OBJECTIVE: The purpose of this study was to investigate the inheritance and phenotype of retinal dysplasia (RD) in the American pit bull terrier. ANIMALS STUDIED: A breeding colony established from a single female pure-bred American pit bull terrier dog with RD. PROCEDURES: A female pure-bred American pit bull terrier with RD was donated to the Veterinary Hospital of Federal University of Paraná, Curitiba, Brazil. A breeding colony was established and the phenotype and inheritance of the condition investigated. Regular ophthalmic examinations and fundus photography were performed on three generations of offspring from the founder animal. Some animals were additionally studied by optical coherence tomography. Ocular histopathology was performed on some animals from the colony. RESULTS: Fifty-seven offspring were produced in two generations from the affected founder female. Thirty-two were diagnosed with RD and showed a spectrum of severity of lesions including multifocal, and or geographic lesions and some developed retinal detachment. Histologic examination demonstrated retinal folds, rosettes, and areas of retinal detachment. The affected dogs were shorter in stature than the unaffected littermates. Breeding studies suggested the trait has an autosomal dominant mode of inheritance. DNA testing showed that the affected dogs were negative for the known gene mutations for canine dwarfism with RD. CONCLUSION: This is a report of a novel inherited form of RD that affects American pit bull terriers.
Authors: Simone Iwabe; Valerie L Dufour; José M Guzmán; Dolores M Holle; Julie A Cohen; William A Beltran; Gustavo D Aguirre Journal: Vet Ophthalmol Date: 2019-11-20 Impact factor: 1.644
Authors: Ana Ripolles-Garcia; Dolores M Holle; Julie A Cohen; William A Beltran; Gustavo D Aguirre Journal: Vet Ophthalmol Date: 2021-11-22 Impact factor: 1.444