Literature DB >> 25521938

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

Henrique Lemos1, Lei Huang, Tracy McGaha, Andrew L Mellor.   

Abstract

DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

Entities:  

Keywords:  DNA; STING; autoimmunity; cancer; immunity; immunotherapy; nanoparticles; tolerance

Mesh：

Substances：

Year:  2014        PMID： 25521938      PMCID： PMC4387570          DOI： 10.1586/1744666X.2015.995097

Source DB:  PubMed          Journal:  Expert Rev Clin Immunol        ISSN： 1744-666X            Impact factor:   4.473


  71 in total

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Journal:  Nature       Date:  2006-10-26       Impact factor: 49.962

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Journal:  J Immunol       Date:  2013-04-12       Impact factor: 5.422

6.  TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus.

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Journal:  Cancer Gene Ther       Date:  2010-01       Impact factor: 5.987

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Authors:  Glen N Barber
Journal:  Trends Immunol       Date:  2013-12-02       Impact factor: 16.687

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10.  Structural mechanism of cytosolic DNA sensing by cGAS.

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  7 in total

Review 1.  The Emerging Roles of STING in Bacterial Infections.

Authors:  Fabio V Marinho; Sulayman Benmerzoug; Sergio C Oliveira; Bernhard Ryffel; V F J Quesniaux
Journal:  Trends Microbiol       Date:  2017-06-15       Impact factor: 17.079

2.  Varicella-Zoster Virus and the Enteric Nervous System.

Authors:  Michael Gershon; Anne Gershon
Journal:  J Infect Dis       Date:  2018-09-22       Impact factor: 5.226

3.  Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity.

Authors:  A A Latanova; S Petkov; A Kilpelainen; J Jansons; O E Latyshev; Y V Kuzmenko; J Hinkula; M A Abakumov; V T Valuev-Elliston; M Gomelsky; V L Karpov; F Chiodi; B Wahren; D Y Logunov; E S Starodubova; M G Isaguliants
Journal:  Sci Rep       Date:  2018-05-24       Impact factor: 4.379

Review 4.  Type I interferons and endoplasmic reticulum stress in health and disease.

Authors:  Jenny Sprooten; Abhishek D Garg
Journal:  Int Rev Cell Mol Biol       Date:  2019-11-19       Impact factor: 6.813

5.  SAMHD1 can suppress lung adenocarcinoma progression through the negative regulation of STING.

Authors:  Yun Wu; Yuxu Niu; Yue Wu; Xiaoyu Chen; Xiaoyong Shen; Wen Gao
Journal:  J Thorac Dis       Date:  2021-01       Impact factor: 2.895

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Authors:  Romina Mitarotonda; Exequiel Giorgi; Tatiane Eufrasio-da-Silva; Alireza Dolatshahi-Pirouz; Yogendra Kumar Mishra; Ali Khademhosseini; Martin F Desimone; Mauricio De Marzi; Gorka Orive
Journal:  Biomater Adv       Date:  2022-04-22

Review 7.  STING: infection, inflammation and cancer.

Authors:  Glen N Barber
Journal:  Nat Rev Immunol       Date:  2015-12       Impact factor: 53.106
  7 in total

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