BACKGROUND: The purpose of this study was to evaluate the individual and combined relationship of comorbidity and performance status (PS) on head and neck squamous cell carcinoma (HNSCC) survival. METHODS: Six hundred patients with HNSCC were prospectively recruited. Comorbidity and PS were measured using the Charlson Comorbidity Index (CCI) and the Eastern Cooperative Oncology Group (ECOG) Scale. Outcomes were overall survival (OS) and cancer-specific survival (CSS). RESULTS: A total of 48.3% of the patients had at least 1 comorbidity, and 42.3% had impaired PS at baseline. There was no correlation between CCI and ECOG (Spearman's ρ = 0.033; p = .42). In multivariate analysis, CCI score was significantly associated with OS (p = .01). ECOG was not associated with OS, but seems to act as an effect modifier in the association between comorbidity and OS. CCI and ECOG were not associated with CSS. CONCLUSION: CCI and ECOG scores both provide prognostic information in predicting OS in HNSCC, but a significant association with CSS was not observed.
BACKGROUND: The purpose of this study was to evaluate the individual and combined relationship of comorbidity and performance status (PS) on head and neck squamous cell carcinoma (HNSCC) survival. METHODS: Six hundred patients with HNSCC were prospectively recruited. Comorbidity and PS were measured using the Charlson Comorbidity Index (CCI) and the Eastern Cooperative Oncology Group (ECOG) Scale. Outcomes were overall survival (OS) and cancer-specific survival (CSS). RESULTS: A total of 48.3% of the patients had at least 1 comorbidity, and 42.3% had impaired PS at baseline. There was no correlation between CCI and ECOG (Spearman's ρ = 0.033; p = .42). In multivariate analysis, CCI score was significantly associated with OS (p = .01). ECOG was not associated with OS, but seems to act as an effect modifier in the association between comorbidity and OS. CCI and ECOG were not associated with CSS. CONCLUSION: CCI and ECOG scores both provide prognostic information in predicting OS in HNSCC, but a significant association with CSS was not observed.
Authors: Sarah Schimansky; Samantha Lang; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steve Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andy Ness Journal: Head Neck Date: 2018-12-14 Impact factor: 3.147
Authors: I Pajares Bernad; J Martínez Trufero; L Calera Urquizu; R A Pazo Cid; A Cebollero de Miguel; M J Agustin; M Lanzuela; A Antón Journal: Clin Transl Oncol Date: 2017-01-24 Impact factor: 3.340
Authors: John M David; Sungjin Kim; Veronica R Placencio-Hickok; Arman Torosian; Andrew Hendifar; Richard Tuli Journal: Adv Radiat Oncol Date: 2018-11-09
Authors: Pei Yuan Fong; Sze Huey Tan; Darren Wan Teck Lim; Eng Huat Tan; Quan Sing Ng; Kiattisa Sommat; Daniel Shao Weng Tan; Mei Kim Ang Journal: PLoS One Date: 2019-11-20 Impact factor: 3.240
Authors: Allison Magnuson; Suanna S Bruinooge; Harpreet Singh; Keith D Wilner; Shadia Jalal; Stuart M Lichtman; Paul G Kluetz; Gary H Lyman; Heidi D Klepin; Mark E Fleury; Brad Hirsch; Allen Melemed; Fernanda I Arnaldez; Upal Basu Roy; Caroline Schenkel; Shimere Sherwood; Elizabeth Garrett-Mayer Journal: Clin Cancer Res Date: 2021-02-09 Impact factor: 13.801