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Literature DB >> 25521371

Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.

Abstract

Accumulation of glutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs. In the current issue of Neuron, Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also provide the conductances necessary to maintain the appropriate voltage and pH inside these vesicles.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 25521371 PMCID： PMC7263376 DOI： 10.1016/j.neuron.2014.12.008

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

12 in total

1. Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels.

Authors: Pablo Artigas; David C Gadsby
Journal: Proc Natl Acad Sci U S A Date: 2002-12-23 Impact factor: 11.205

2. A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles.

Authors: Stephan Schenck; Sonja M Wojcik; Nils Brose; Shigeo Takamori
Journal: Nat Neurosci Date: 2009-01-25 Impact factor: 24.884

3. Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter.

Authors: Julia Preobraschenski; Johannes-Friedrich Zander; Toshiharu Suzuki; Gudrun Ahnert-Hilger; Reinhard Jahn
Journal: Neuron Date: 2014-11-26 Impact factor: 17.173

Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.

1. Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels.

2. A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles.

3. Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter.

Review 4. Vesicular neurotransmitter transporter: bioenergetics and regulation of glutamate transport.

5. Vesicular glutamate transporter contains two independent transport machineries.

6. Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.

7. Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis.

8. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel.

9. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.

10. Metabolic control of vesicular glutamate transport and release.

Review 1. VGLUTs and Glutamate Synthesis-Focus on DRG Neurons and Pain.