Angela Hong1,2, C Soon Lee1,3, Deanna Jones4, Anne-Sophie Veillard5, Mei Zhang1,2, Xiaoying Zhang1, Robert Smee6, June Corry7, Sandro Porceddu8, Christopher Milross1,2, Michael Elliott9, Jonathan Clark1,9, Barbara Rose4. 1. Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia. 2. Department of Radiation Oncology, Lifehouse, Sydney, New South Wales, Australia. 3. Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. 4. Department of Infectious Diseases and Immunology, The University of Sydney, Sydney, New South Wales, Australia. 5. NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia. 6. Department of Radiation Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia. 7. Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. 8. Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia. 9. Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Abstract
BACKGROUND: This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades. METHODS: The HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6-targeted multiplex real time polymerase chain reaction assay (PCR) and p16 immunohistochemistry. RESULTS: The HPV positivity rate increased from 20.2% (1987-1995) to 63.5% (2006-2010). Among HPV-positive oropharyngeal SCC over the study period, the median age increased from 55.4 years to 59.8 years (p = .004) and there was a trend of an increasing proportion of never smokers (19.2% to 34.0%). The use of radiation therapy (RT) in patients with HPV-positive oropharyngeal cancer increased from 26.9% to 68.1% (p = .007) and we also observed a trend of improved outcomes. CONCLUSION: Our data show a rising prevalence of HPV-positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV-positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked.
BACKGROUND: This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades. METHODS: The HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6-targeted multiplex real time polymerase chain reaction assay (PCR) and p16 immunohistochemistry. RESULTS: The HPV positivity rate increased from 20.2% (1987-1995) to 63.5% (2006-2010). Among HPV-positive oropharyngeal SCC over the study period, the median age increased from 55.4 years to 59.8 years (p = .004) and there was a trend of an increasing proportion of never smokers (19.2% to 34.0%). The use of radiation therapy (RT) in patients with HPV-positive oropharyngeal cancer increased from 26.9% to 68.1% (p = .007) and we also observed a trend of improved outcomes. CONCLUSION: Our data show a rising prevalence of HPV-positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV-positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked.
Authors: J Chandra; W P Woo; N Finlayson; H Y Liu; M McGrath; R Ladwa; M Brauer; Y Xu; S Hanson; B Panizza; I H Frazer; Sandro V Porceddu Journal: Cancer Immunol Immunother Date: 2020-09-12 Impact factor: 6.968
Authors: Valentina Lupato; Dana Holzinger; Daniela Höfler; Anna Menegaldo; Paolo Giorgi Rossi; Annarosa Del Mistro; Maria Cristina Da Mosto; Michael Pawlita; Paolo Boscolo-Rizzo Journal: PLoS One Date: 2017-01-19 Impact factor: 3.240
Authors: Mushfiq H Shaikh; Aminul I Khan; Anwar Sadat; Ahmed H Chowdhury; Shahed A Jinnah; Vinod Gopalan; Alfred K Lam; Daniel T W Clarke; Nigel A J McMillan; Newell W Johnson Journal: BMC Cancer Date: 2017-11-25 Impact factor: 4.430
Authors: Angela M Hong; Ricardo E Vilain; Sarah Romanes; Jean Yang; Elizabeth Smith; Deanna Jones; Richard A Scolyer; C Soon Lee; Mei Zhang; Barbara Rose Journal: Oncotarget Date: 2016-11-22