Benjamin Weinkauf1,2, Saskia Deising2, Otilia Obreja2, Ulrich Hoheisel3, Siegfried Mense3, Martin Schmelz2, Roman Rukwied2. 1. Department of Orthopedics and Traumatology, University Medical Center Mannheim, Mannheim, Germany. 2. Department of Anesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. 3. Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.
Abstract
INTRODUCTION:Nerve growth factor (NGF) induces profound hyperalgesia. In this study we explored patterns of NGF sensitization in muscle and fascia of distal and paraspinal sites. METHODS: We injected 1 µg of NGF into human (n = 8) tibialis anterior and erector spinae muscles and their fasciae. The spatial extent of pressure sensitization, pressure pain threshold, and mechanical hyperalgesia (150 kPa, 10 s) was assessed at days 0.25, 1, 3, 7, 14, and 21. Chemical sensitization was explored by acidic buffer injections (pH 4, 100 µl) at days 7 and 14. RESULTS: The mechanical hyperalgesia area was larger in tibial fascia than in muscle. Pressure pain thresholds were lower, tonic pressure pain ratings, and citrate buffer evoked pain higher in fascia than in muscle. CONCLUSIONS: Spatial mechanical sensitization differs between muscle and fascia. Thoracolumbar fasciae appear more sensitive than tibial fasciae and may be major contributors to low back pain, but the temporal sensitization profile is similar between paraspinal and distal sites. Muscle Nerve 52: 265-272, 2015.
RCT Entities:
INTRODUCTION: Nerve growth factor (NGF) induces profound hyperalgesia. In this study we explored patterns of NGF sensitization in muscle and fascia of distal and paraspinal sites. METHODS: We injected 1 µg of NGF into human (n = 8) tibialis anterior and erector spinae muscles and their fasciae. The spatial extent of pressure sensitization, pressure pain threshold, and mechanical hyperalgesia (150 kPa, 10 s) was assessed at days 0.25, 1, 3, 7, 14, and 21. Chemical sensitization was explored by acidic buffer injections (pH 4, 100 µl) at days 7 and 14. RESULTS: The mechanical hyperalgesia area was larger in tibial fascia than in muscle. Pressure pain thresholds were lower, tonic pressure pain ratings, and citrate buffer evoked pain higher in fascia than in muscle. CONCLUSIONS: Spatial mechanical sensitization differs between muscle and fascia. Thoracolumbar fasciae appear more sensitive than tibial fasciae and may be major contributors to low back pain, but the temporal sensitization profile is similar between paraspinal and distal sites. Muscle Nerve 52: 265-272, 2015.
Authors: Walter Magerl; Emanuela Thalacker; Simon Vogel; Robert Schleip; Thomas Klein; Rolf-Detlef Treede; Andreas Schilder Journal: Life (Basel) Date: 2021-04-21
Authors: William R Reed; Joshua W Little; Carla R Lima; Robert E Sorge; Ceren Yarar-Fisher; Mualla Eraslan; Christopher P Hurt; Timothy J Ness; Jianguo G Gu; Daniel F Martins; Peng Li Journal: Front Neurosci Date: 2020-04-30 Impact factor: 4.677
Authors: John D Markman; Robert B Bolash; Timothy E McAlindon; Alan J Kivitz; Manuel Pombo-Suarez; Seiji Ohtori; Frank W Roemer; David J Li; Lars Viktrup; Candace Bramson; Christine R West; Kenneth M Verburg Journal: Pain Date: 2020-09-01 Impact factor: 7.926