| Literature DB >> 2552118 |
J W Lown1, K Krowicki, J Balzarini, R A Newman, E De Clercq.
Abstract
A group of oligopeptides have been synthesized which are structurally related to the natural antiviral antitumor antibiotics netropsin and distamycin bearing two such moieties linked by polymethylene bridges. Cytostatic activity against both human and murine tumor cell lines and their in vitro activity against a range of viruses are reported. Enhanced antiviral activity was obtained against vaccinia virus. As a result of the introduction of the polymethylene linkers [( CH2)n, with n = 1, 2, and 6-8], both the antitumor and antivaccinia virus activity was markedly enhanced, relative to that of the parent compounds netropsin and distamycin. The biological activity of these agents is discussed both in terms of their structural differences and in relation to their minor groove binding to duplex DNA.Entities:
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Year: 1989 PMID： 2552118 DOI： 10.1021/jm00130a024
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446