Literature DB >> 25520281

Neuropathological Techniques to Investigate Central Nervous System Sections in Multiple Sclerosis.

Jan Bauer1, Hans Lassmann.   

Abstract

Immunohistochemical techniques (IHC) and in situ hybridization (ISH) are widely used techniques to study the expression of proteins and messenger RNAs in tissues and are extremely important to confirm and interpret biochemical and molecular results from the same tissues. Investigation of human brain by IHC and ISH therefore still plays an important role in the elucidation of pathogenetic mechanisms in diseases such as multiple sclerosis. In this review we describe the processing of human brain tissues as well as basic and advanced immunohistochemical staining and ISH techniques used for neuropathological analysis of such pathological brains.

Entities:  

Mesh：

Year:  2016        PMID： 25520281     DOI： 10.1007/7651_2014_151

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  16 in total

1.  IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.

Authors:  Lidia Yshii; Béatrice Pignolet; Emilie Mauré; Mandy Pierau; Monika Brunner-Weinzierl; Oliver Hartley; Jan Bauer; Roland Liblau
Journal:  JCI Insight       Date:  2019-04-04

2.  Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.

Authors:  Michael Winklehner; Jan Bauer; Verena Endmayr; Carmen Schwaiger; Gerda Ricken; Masakatsu Motomura; Shunsuke Yoshimura; Hiroshi Shintaku; Kinya Ishikawa; Yukio Tsuura; Takahiro Iizuka; Takanori Yokota; Takashi Irioka; Romana Höftberger
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2022-07-07

3.  Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis.

Authors:  Susanne Laukoter; Helmut Rauschka; Anna R Tröscher; Ulrike Köck; Etsuji Saji; Kurt Jellinger; Hans Lassmann; Jan Bauer
Journal:  Acta Neuropathol       Date:  2016-11-05       Impact factor: 17.088

4.  Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis.

Authors:  Stoyan Popkirov; Ilya Ayzenberg; Stefanie Hahn; Jan Bauer; Yvonne Denno; Nicole Rieckhoff; Christiane Radzimski; Volkmar H Hans; Sebastian Berg; Florian Roghmann; Joachim Noldus; Christian G Bien; Sabine Skodda; Jörg Wellmer; Winfried Stöcker; Christos Krogias; Ralf Gold; Uwe Schlegel; Christian Probst; Lars Komorowski; Ramona Miske; Ingo Kleiter
Journal:  Acta Neuropathol Commun       Date:  2017-05-29       Impact factor: 7.801

5.  Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.

Authors:  Tobias Zrzavy; Simon Hametner; Isabella Wimmer; Oleg Butovsky; Howard L Weiner; Hans Lassmann
Journal:  Brain       Date:  2017-07-01       Impact factor: 13.501

6.  Pro-inflammatory activation of microglia in the brain of patients with sepsis.

Authors:  T Zrzavy; R Höftberger; T Berger; H Rauschka; O Butovsky; H Weiner; H Lassmann
Journal:  Neuropathol Appl Neurobiol       Date:  2018-06-19       Impact factor: 8.090

7.  Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts.

Authors:  Tobias Zrzavy; Joana Machado-Santos; Sheren Christine; Christoph Baumgartner; Howard L Weiner; Oleg Butovsky; Hans Lassmann
Journal:  Brain Pathol       Date:  2017-12-28       Impact factor: 6.508

8.  Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself.

Authors:  Saskia Maria Burm; Laura Anna Norma Peferoen; Ella Alwine Zuiderwijk-Sick; Krista Geraldine Haanstra; Bert Adriaan 't Hart; Paul van der Valk; Sandra Amor; Jan Bauer; Jeffrey John Bajramovic
Journal:  J Neuroinflammation       Date:  2016-06-06       Impact factor: 8.322

9.  The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.

Authors:  Joana Machado-Santos; Etsuji Saji; Anna R Tröscher; Manuela Paunovic; Roland Liblau; Galina Gabriely; Christian G Bien; Jan Bauer; Hans Lassmann
Journal:  Brain       Date:  2018-07-01       Impact factor: 15.255

10.  Microglial nodules provide the environment for pathogenic T cells in human encephalitis.

Authors:  Anna R Tröscher; Isabella Wimmer; Lucía Quemada-Garrido; Ulrike Köck; Denise Gessl; Sanne G S Verberk; Bethany Martin; Hans Lassmann; Christian G Bien; Jan Bauer
Journal:  Acta Neuropathol       Date:  2019-01-20       Impact factor: 17.088
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.