Literature DB >> 2552027

Herpes simplex virus (HSV) DNA in microglial nodular brainstem encephalitis.

M Schmidbauer1, H Budka, P Ambros.   

Abstract

Thirty-four brains with microglial nodular brain stem encephalitis were retrospectively investigated for herpes simplex virus (HSV) and cytomegalovirus (CMV) by in situ hybridization (ISH) with biotinylated cDNA probes, and by immunocytochemistry with polyclonal and monoclonal antibodies on formalin fixed paraffin embedded serial tissue sections. In 16 cases (47%), HSV DNA was found by ISH in the nuclei of neurons in microglial nodules or in the adjacent parenchyma of the brainstem, and more rarely at various cerebellar and telencephalic sites. None of the 34 cases was labeled for CMV DNA and none revealed HSV or CMV antigens. Ten control brains without microglial nodules were not labeled. This study suggests an HSV etiology for many cases with microglial nodular brainstem encephalitis.

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Year:  1989        PMID： 2552027     DOI： 10.1097/00005072-198911000-00006

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN： 0022-3069            Impact factor:   3.685


  9 in total

Review 1.  The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis.

Authors:  P Cinque; G M Cleator; T Weber; P Monteyne; C J Sindic; A M van Loon
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-10       Impact factor: 10.154

2.  Progressive multifocal leukoencephalopathy (PML) in AIDS and in the pre-AIDS era. A neuropathological comparison using immunocytochemistry and in situ DNA hybridization for virus detection.

Authors:  M Schmidbauer; H Budka; K V Shah
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

Review 3.  Human immunodeficiency virus (HIV)-induced disease of the central nervous system: pathology and implications for pathogenesis.

Authors:  H Budka
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

4.  Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues.

Authors:  Shih-Heng Chen; Hui-Wen Yao; Wen-Yen Huang; Kuei-Sen Hsu; Huan-Yao Lei; Ai-Li Shiau; Shun-Hua Chen
Journal:  J Virol       Date:  2006-09-27       Impact factor: 5.103

5.  Cytomegalovirus (CMV) disease of the brain in AIDS and connatal infection: a comparative study by histology, immunocytochemistry and in situ DNA hybridization.

Authors:  M Schmidbauer; H Budka; W Ulrich; P Ambros
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

Review 6.  Molecular methods for diagnosis of viral encephalitis.

Authors:  Roberta L Debiasi; Kenneth L Tyler
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

7.  Human immunodeficiency virus (HIV) envelope and core proteins in CNS tissues of patients with the acquired immune deficiency syndrome (AIDS).

Authors:  H Budka
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

8.  Resistance of rat CNS to brain stem infection with herpes simplex virus type 1.

Authors:  T Bergström; N Conradi; E Hansson; A Liljeroth; A Vahlne
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

9.  Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1.

Authors:  S Kesari; V M Lee; S M Brown; J Q Trojanowski; N W Fraser
Journal:  J Neurosci       Date:  1996-09-15       Impact factor: 6.167
  9 in total

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