| Literature DB >> 25520005 |
Huijuan Jin1,2, Lei Pei1,2, Xiaogang Shu3,2, Xin Yang1,2, Tianhua Yan4, Yan Wu3,2, Na Wei1,2, Honglin Yan1,2, Shan Wang1,2, Chengye Yao1,2, Dan Liu5,2, Qing Tian2, Lin Wang6,7, Youming Lu8,9.
Abstract
Cognition in all mammals including human beings declines during aging. The cellular events responsible for this decay involve a reduction of neurogenesis in the dentate gyrus. Here, we show that treatment with a nature product from a traditional Chinese medicine, namely salidroside restores the capacity of the dentate gyrus to generate new neurons and intercepts learning and memory decays in mice during aging. We uncover that new neurons in aging mice have functional features of an adult granule neuron by forming excitatory synapses with their putative targeting neurons. Genetic inhibition of synaptic transmission from new neurons abolishes the therapeutic effects of salidroside in behavioral tests. We also identify that salidroside targets CREB transcription for the survival of new neurons in the dentate gyrus of old mice. Thus, salidroside is therapeutically effective against learning and memory decays via stimulation of CREB-dependent functional neurogenesis in aging.Entities:
Keywords: Aging; CREB; Learning and memory decays; Neurogenesis; Salidroside
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Year: 2014 PMID： 25520005 DOI： 10.1007/s12035-014-9045-6
Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590