OBJECTIVE: This study aims to evaluate the relationship between early-onset severe preeclampsia and first trimester serum levels of pregnancy-associated plasma protein A (PAPP-A) and total human chorionic gonadotropin (hCG). STUDY DESIGN: The association between early-onset severe preeclampsia and abnormal levels of first trimester PAPP-A and total hCG in maternal serum were measured in a sample of singleton pregnancies without chromosomal defects that had integrated prenatal serum screening in 2009 and 2010 (n = 129,488). Logistic binomial regression was used to estimate the relative risk (RR) of early-onset severe preeclampsia in pregnancies with abnormal levels of first trimester PAPP-A or total hCG as compared with controls. RESULTS: Regardless of parity, women with low first trimester PAPP-A or high total hCG were at increased risk for early-onset severe preeclampsia. Women with low PAPP-A (multiple of the median [MoM] ≤ the 10th percentile in nulliparous or ≤ the 5th percentile in multiparous) or high total hCG (MoM ≥ the 90th percentile in nulliparous or ≥ the 95th percentile in multiparous) were at more than a threefold increased risk for early-onset severe preeclampsia (RR, 4.2; 95% confidence interval [CI], 3.0-5.9 and RR, 3.3; 95% CI, 2.1-5.2, respectively). CONCLUSION: Routinely collected first trimester measurements of PAPP-A and total hCG provide unique risk information for early-onset severe preeclampsia. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: This study aims to evaluate the relationship between early-onset severe preeclampsia and first trimester serum levels of pregnancy-associated plasma protein A (PAPP-A) and total human chorionic gonadotropin (hCG). STUDY DESIGN: The association between early-onset severe preeclampsia and abnormal levels of first trimester PAPP-A and total hCG in maternal serum were measured in a sample of singleton pregnancies without chromosomal defects that had integrated prenatal serum screening in 2009 and 2010 (n = 129,488). Logistic binomial regression was used to estimate the relative risk (RR) of early-onset severe preeclampsia in pregnancies with abnormal levels of first trimester PAPP-A or total hCG as compared with controls. RESULTS: Regardless of parity, women with low first trimester PAPP-A or high total hCG were at increased risk for early-onset severe preeclampsia. Women with low PAPP-A (multiple of the median [MoM] ≤ the 10th percentile in nulliparous or ≤ the 5th percentile in multiparous) or high total hCG (MoM ≥ the 90th percentile in nulliparous or ≥ the 95th percentile in multiparous) were at more than a threefold increased risk for early-onset severe preeclampsia (RR, 4.2; 95% confidence interval [CI], 3.0-5.9 and RR, 3.3; 95% CI, 2.1-5.2, respectively). CONCLUSION: Routinely collected first trimester measurements of PAPP-A and total hCG provide unique risk information for early-onset severe preeclampsia. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Rebecca J Baer; Monica R McLemore; Nancy Adler; Scott P Oltman; Brittany D Chambers; Miriam Kuppermann; Matthew S Pantell; Elizabeth E Rogers; Kelli K Ryckman; Marina Sirota; Larry Rand; Laura L Jelliffe-Pawlowski Journal: Eur J Obstet Gynecol Reprod Biol Date: 2018-11-05 Impact factor: 2.435
Authors: Matthew B Wallenstein; Laura L Jelliffe-Pawlowski; Wei Yang; Suzan L Carmichael; David K Stevenson; Kelli K Ryckman; Gary M Shaw Journal: J Matern Fetal Neonatal Med Date: 2015-12-23
Authors: Laura L Jelliffe-Pawlowski; Larry Rand; Bruce Bedell; Rebecca J Baer; Scott P Oltman; Mary E Norton; Gary M Shaw; David K Stevenson; Jeffrey C Murray; Kelli K Ryckman Journal: J Perinatol Date: 2018-05-24 Impact factor: 3.225
Authors: M Barjaktarovic; T I M Korevaar; V W V Jaddoe; Y B de Rijke; R P Peeters; E A P Steegers Journal: Ultrasound Obstet Gynecol Date: 2019-10 Impact factor: 7.299