Literature DB >> 2551868

Rearranged Epstein-Barr virus genomes and clonal origin in nasopharyngeal carcinoma.

M Shimakage1, M Chatani, N Ikegami, K Hirai.   

Abstract

Epstein-Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NPC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single-sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV-infected cell.

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Year:  1989        PMID： 2551868      PMCID： PMC5917820          DOI： 10.1111/j.1349-7006.1989.tb01685.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  16 in total

1.  Nasopharyngeal carcinoma. X. Presence of epstein-barr genomes in separated epithelial cells of tumours in patients from Singapore, Tunisia and Kenya.

Authors:  C Desgranges; H Wolf; G De-Thé; K Shanmugaratnam; N Cammoun; R Ellouz; G Klein; K Lennert; N Muñoz; H Zur Hausen
Journal:  Int J Cancer       Date:  1975-07-15       Impact factor: 7.396

2.  Serological follow-up study on the antibody levels to Epstein-Barr virus-determined nuclear antigen (EBNA) patients with nasopharyngeal carcinoma (NPC) after radiation therapy.

Authors:  M Shimakage; N Ikegami; M Chatani; K Yoshino; T Sato
Journal:  Biken J       Date:  1987-06

3.  Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus.

Authors:  M L Cleary; M A Nalesnik; W T Shearer; J Sklar
Journal:  Blood       Date:  1988-07       Impact factor: 22.113

4.  Two deletions in the Epstein-Barr virus genome of the Burkitt lymphoma nonproducer line Raji.

Authors:  A Polack; H Delius; U Zimber; G W Bornkamm
Journal:  Virology       Date:  1984-02       Impact factor: 3.616

5.  Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.

Authors:  F Wang; C D Gregory; M Rowe; A B Rickinson; D Wang; M Birkenbach; H Kikutani; T Kishimoto; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

6.  Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection.

Authors:  W Henle; G Henle; J Andersson; I Ernberg; G Klein; C A Horwitz; G Marklund; L Rymo; C Wellinder; S E Straus
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

7.  The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA.

Authors:  N Raab-Traub; K Flynn; G Pearson; A Huang; P Levine; A Lanier; J Pagano
Journal:  Int J Cancer       Date:  1987-01-15       Impact factor: 7.396

8.  Epstein-Barr virus lymphoproliferation after bone marrow transplantation.

Authors:  M M Zutter; P J Martin; G E Sale; H M Shulman; L Fisher; E D Thomas; D M Durnam
Journal:  Blood       Date:  1988-08       Impact factor: 22.113

9.  Detection of Epstein-Barr viral DNA internal repeats in the nasopharyngeal mucosa of Chinese with IgA/EBV-specific antibodies.

Authors:  C Desgranges; G W Bornkamm; Y Zeng; P C Wang; J S Zhu; M Shang; G De-Thé
Journal:  Int J Cancer       Date:  1982-01-15       Impact factor: 7.396

10.  Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection.

Authors:  S Ishihara; A Tawa; K Yumura-Yagi; M Murata; J Hara; H Yabuuchi; K Hirai; K Kawa-Ha
Journal:  Jpn J Cancer Res       Date:  1989-02
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