[Mechanism of prostate cancer invasion and metastasis].

Prostate cancer cells pass through numerous steps during the process of progression and metastasis. Cancer cells from primary site undertake "epithelial-mesenchymal transition (EMT)" and migrate into neighboring site and invade into blood vessels. Migrated cancer cells will detach from extracellular matrix (ECM) and float into distant metastasis site. Those detached cells will go through either "apoptosis" or acquire "anoikis resistance" and, finally, transfer to distant metastasis site. When settle at novel metastasis site, "mesenchymal-epithelial transition (MET)" will take place. Receptor activator of nuclear factor κ-B ligand (RANKL) plays significant role in formation of bone metastasis site.