| Literature DB >> 2551777 |
T Johansen1, T Holm, E Bjørklid.
Abstract
A cDNA clone homologous to the RTVL-H family of human retrovirus-like elements was isolated from a human placenta cDNA library. The nucleotide sequence of the 1084-bp cDNA revealed an open reading frame (ORF) that may encode a 146 amino acid protein with significant homology to retroviral proteases. Downstream from the putative protease ORF a 3' long terminal repeat (LTR) containing U3 and R regions was found. The cDNA sequence ends in a poly(A) tail appropriately positioned downstream from a polyadenylation signal in the LTR. Northern-blot analysis showed that several distinct RTVL-H homologous transcripts are present in human placenta. We also show that repetitive RTVL-H homologous sequences are present in the genomes of both gorilla and African green monkey.Entities:
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Year: 1989 PMID： 2551777 DOI： 10.1016/0378-1119(89)90208-4
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688