| Literature DB >> 25517745 |
Joan Sanchez-Gurmaches1, David A Guertin2.
Abstract
A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.Entities:
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Year: 2014 PMID： 25517745 DOI： 10.1016/j.ccell.2014.10.011
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743