Literature DB >> 25517460

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

Jake A Kushner1, Patrick E MacDonald2, Mark A Atkinson3.   

Abstract

Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss implications for type 1 diabetes research and clinical care.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Mesh：

Year:  2014        PMID： 25517460     DOI： 10.1016/j.stem.2014.10.012

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  16 in total

Review 1.  Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells.

Authors:  Gopika Nair; Matthias Hebrok
Journal:  Curr Opin Genet Dev       Date:  2015-04-21       Impact factor: 5.578

Review 2.  The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds.

Authors:  James D Johnson
Journal:  Diabetologia       Date:  2016-07-29       Impact factor: 10.122

3.  In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development.

Authors:  Jia Zhao; Weijian Zong; Yiwen Zhao; Dongzhou Gou; Shenghui Liang; Jiayu Shen; Yi Wu; Xuan Zheng; Runlong Wu; Xu Wang; Fuzeng Niu; Aimin Wang; Yunfeng Zhang; Jing-Wei Xiong; Liangyi Chen; Yanmei Liu
Journal:  Elife       Date:  2019-01-29       Impact factor: 8.140

Review 4.  Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style.

Authors:  Allyson J Merrell; Ben Z Stanger
Journal:  Nat Rev Mol Cell Biol       Date:  2016-03-16       Impact factor: 94.444

5.  A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform.

Authors:  Zhengshan Zhao; Yassan Abdolazimi; Neali A Armstrong; Justin P Annes
Journal:  J Vis Exp       Date:  2016-07-16       Impact factor: 1.355

Review 6.  Insulin-secreting β cells require a post-genomic concept.

Authors:  Fang-Xu Jiang; Grant Morahan
Journal:  World J Diabetes       Date:  2016-05-25

7.  Exploring the effect of epigenetic modifiers on developing insulin-secreting cells.

Authors:  Ibrahim Elsharkawi; Divyasree Parambath; Maha Saber-Ayad; Amir Ali Khan; Ahmed T El-Serafi
Journal:  Hum Cell       Date:  2019-11-21       Impact factor: 4.174

Review 8.  Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges.

Authors:  Ali Golchin; Alexia Chatziparasidou; Parviz Ranjbarvan; Zahra Niknam; Abdolreza Ardeshirylajimi
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

9.  Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation.

Authors:  Tiziana Sanavia; Chen Huang; Elisabetta Manduchi; Yanwen Xu; Prasanna K Dadi; Leah A Potter; David A Jacobson; Barbara Di Camillo; Mark A Magnuson; Christian J Stoeckert; Guoqiang Gu
Journal:  Front Cell Dev Biol       Date:  2021-05-04

10.  Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice.

Authors:  Aaron R Cox; Carol J Lam; Claire W Bonnyman; Julia Chavez; Jacqueline S Rios; Jake A Kushner
Journal:  Diabetologia       Date:  2015-04-28       Impact factor: 10.122
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