| Literature DB >> 25517413 |
Stephanie J Conn1, Shannon M Vreeland, Alexandra N Wexler, Rebecca H Pouwer, Rebecca N Pouwer, Ronald J Quinn, Stephen Chamberland.
Abstract
The first total synthesis of the potent and selective human blood coagulation factor XIa inhibitor clavatadine A (1) is described. Direct, early-stage guanidinylation enabled rapid, convergent access to an immediate clavatadine A precursor. Concomitant lactone hydrolysis and guanidine deprotection with aqueous acid cleanly provided clavatadine A (1) in only four steps (longest linear sequence, 41-43% overall yield).Entities:
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Year: 2014 PMID： 25517413 DOI： 10.1021/np500772u
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050