Theo L Peeters1. 1. Gut Peptide Laboratory, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
Abstract
PURPOSE OF REVIEW: To summarize the recent findings. RECENT FINDINGS: Studies of changes in the plasma levels confirm the earlier concepts, but offer little proof of causal effect. It is increasingly realized that peptides produced in the gut have a paracrine role or an indirect effect via the gut-brain axis. Interest in prokinetic peptide agonists remains high despite the failure of two candidate drugs, but relamorelin and camicinal offer new hope. SUMMARY: We review the original studies published since January 2013 on peptides produced in the gut and with an effect on gastrointestinal motility.
PURPOSE OF REVIEW: To summarize the recent findings. RECENT FINDINGS: Studies of changes in the plasma levels confirm the earlier concepts, but offer little proof of causal effect. It is increasingly realized that peptides produced in the gut have a paracrine role or an indirect effect via the gut-brain axis. Interest in prokinetic peptide agonists remains high despite the failure of two candidate drugs, but relamorelin and camicinal offer new hope. SUMMARY: We review the original studies published since January 2013 on peptides produced in the gut and with an effect on gastrointestinal motility.
Authors: Lotte E Vlug; Patric J D Delhanty; Esther G Neelis; Martin Huisman; Jenny A Visser; Edmond H H M Rings; René M H Wijnen; Sjoerd C J Nagelkerke; Merit M Tabbers; Jessie M Hulst; Barbara A E de Koning Journal: Front Nutr Date: 2022-05-11