Literature DB >> 2551677

A membrane component of the endoplasmic reticulum that may be essential for protein translocation.

E Hartmann1, M Wiedmann, T A Rapoport.   

Abstract

We have purified a glycosylated, membrane-spanning protein of relative molecular mass approximately 34,000 (Mr approximately 34 K) from canine microsomes that appears to be essential for protein translocation across the endoplasmic reticulum (ER) as shown by the inhibitory action of antibodies directed against it and of monovalent Fab-fragments produced from them. The ER membrane contains at least as many molecules of the 34 K membrane protein as bound ribosomes. The protein can be detected immunologically in tissues of various organisms, indicating an universal function.

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Year:  1989        PMID： 2551677      PMCID： PMC401152          DOI： 10.1002/j.1460-2075.1989.tb08346.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  27 in total

1.  Microprocedures for quantitative immunochemical analysis of antigenic molecules and antigenic determinants.

Authors:  K Malinowski; W Manski
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

2.  "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

Authors:  W N Burnette
Journal:  Anal Biochem       Date:  1981-04       Impact factor: 3.365

3.  Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation.

Authors:  R Gilmore; G Blobel
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

4.  Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.

Authors:  P Walter; G Blobel
Journal:  J Cell Biol       Date:  1983-12       Impact factor: 10.539

5.  Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

Authors:  P Walter; G Blobel
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539

6.  Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

Authors:  G Blobel; B Dobberstein
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539

7.  Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

Authors:  R Gilmore; P Walter; G Blobel
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539

8.  Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes.

Authors:  G Kreibich; B L Ulrich; D D Sabatini
Journal:  J Cell Biol       Date:  1978-05       Impact factor: 10.539

9.  Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

Authors:  P Walter; I Ibrahimi; G Blobel
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539

10.  Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

Authors:  R Gilmore; G Blobel; P Walter
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539
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  15 in total

Review 1.  Components and mechanism of protein translocation across the ER membrane.

Authors:  T A Rapoport; D Görlich; A Müsch; E Hartmann; S Prehn; M Wiedmann; A Otto; S Kostka; R Kraft
Journal:  Antonie Van Leeuwenhoek       Date:  1992-02       Impact factor: 2.271

2.  An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane.

Authors:  D L Zimmerman; P Walter
Journal:  Cell Regul       Date:  1991-10

Review 3.  Protein-protein interactions: methods for detection and analysis.

Authors:  E M Phizicky; S Fields
Journal:  Microbiol Rev       Date:  1995-03

Review 4.  The complete general secretory pathway in gram-negative bacteria.

Authors:  A P Pugsley
Journal:  Microbiol Rev       Date:  1993-03

5.  Reconstitution of translocation-competent membrane vesicles from detergent-solubilized dog pancreas rough microsomes.

Authors:  Y H Yu; Y Y Zhang; D D Sabatini; G Kreibich
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

6.  The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents.

Authors:  D Görlich; S Prehn; E Hartmann; J Herz; A Otto; R Kraft; M Wiedmann; S Knespel; B Dobberstein; T A Rapoport
Journal:  J Cell Biol       Date:  1990-12       Impact factor: 10.539

7.  Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.

Authors:  A Nori; A Villa; P Podini; D R Witcher; P Volpe
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

8.  Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary.

Authors:  J C Holthuis; M C van Riel; G J Martens
Journal:  Biochem J       Date:  1995-11-15       Impact factor: 3.857

9.  The secD locus of E.coli codes for two membrane proteins required for protein export.

Authors:  C Gardel; K Johnson; A Jacq; J Beckwith
Journal:  EMBO J       Date:  1990-10       Impact factor: 11.598

10.  A microsomal protein is involved in ATP-dependent transport of presecretory proteins into mammalian microsomes.

Authors:  P Klappa; P Mayinger; R Pipkorn; M Zimmermann; R Zimmermann
Journal:  EMBO J       Date:  1991-10       Impact factor: 11.598
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